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Gene: KDR (kinase insert domain receptor) Homo sapiens
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Symbol: KDR
Name: kinase insert domain receptor
Description: Exhibits several functions, including cell adhesion molecule binding activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including positive regulation of endothelial cell migration; positive regulation of intracellular signal transduction; and protein phosphorylation. Localizes to several cellular components, including the Golgi apparatus; endosome; and membrane raft. Implicated in artery disease (multiple); macular degeneration (multiple); pancreatic cancer; and urinary bladder cancer. Biomarker of several diseases, including breast cancer (multiple); eye disease (multiple); inflammatory bowel disease (multiple); nervous system benign neoplasm (multiple); and systemic scleroderma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD309; fetal liver kinase 1; fetal liver kinase-1; FLK1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; vascular endothelial growth factor receptor 2; VEGFR; VEGFR2
Orthologs:
Mus musculus (house mouse) : Kdr (kinase insert domain protein receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdr (kinase insert domain receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdr (kinase insert domain receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : KDR (kinase insert domain receptor)
Canis lupus familiaris (dog) : KDR (kinase insert domain receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdr (kinase insert domain receptor)
Sus scrofa (pig) : KDR (kinase insert domain receptor)
Chlorocebus sabaeus (African green monkey) : KDR (kinase insert domain receptor)
Heterocephalus glaber (naked mole-rat) : Kdr (kinase insert domain receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl455,078,481 - 55,125,595 (-)EnsemblGRCh38hg38GRCh38
GRCh38455,078,481 - 55,125,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37455,944,426 - 55,991,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,639,406 - 55,686,519 (-)NCBINCBI36hg18NCBI36
Build 34455,785,576 - 55,832,690NCBI
Celera453,446,341 - 53,493,673 (-)NCBI
Cytogenetic Map4q12NCBI
HuRef451,893,013 - 51,940,346 (-)NCBIHuRef
CHM1_1455,979,683 - 56,027,015 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated

Genomics

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RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Additional Information

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Nomenclature History
 
More on KDR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731018
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.