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Gene: SLC8A1 (solute carrier family 8 member A1) Homo sapiens
Symbol: SLC8A1
Name: solute carrier family 8 member A1
CRRD ID: 731021
Description: Exhibits ankyrin binding activity; calcium:sodium antiporter activity; and calmodulin binding activity. Involved in several processes, including cellular sodium ion homeostasis; metal ion transport; and positive regulation of the force of heart contraction. Localizes to integral component of plasma membrane; nucleoplasm; and synapse. Implicated in hypertension. Biomarker of Alzheimer's disease and pulmonary hypertension.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp779F0871; FLJ37694; FLJ43417; MGC119581; Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; NCX1; sodium/calcium exchanger 1; solute carrier family 8 (sodium/calcium exchanger), member 1; solute carrier family 8 member 1
Mus musculus (house mouse) : Slc8a1 (solute carrier family 8 (sodium/calcium exchanger), member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc8a1 (solute carrier family 8 member A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc8a1 (solute carrier family 8 member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC8A1 (solute carrier family 8 member A1)
Canis lupus familiaris (dog) : SLC8A1 (solute carrier family 8 member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc8a1 (solute carrier family 8 member A1)
Sus scrofa (pig) : SLC8A1 (solute carrier family 8 member A1)
Chlorocebus sabaeus (African green monkey) : SLC8A1 (solute carrier family 8 member A1)
Heterocephalus glaber (naked mole-rat) : Slc8a1 (solute carrier family 8 member A1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl240,097,270 - 40,611,053 (-)EnsemblGRCh38hg38GRCh38
GRCh38240,094,523 - 40,512,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37240,339,286 - 40,739,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36240,192,790 - 40,510,948 (-)NCBINCBI36hg18NCBI36
Build 34240,253,795 - 40,569,095NCBI
Celera240,180,223 - 40,580,364 (-)NCBI
Cytogenetic Map2p22.1NCBI
HuRef240,078,719 - 40,478,536 (-)NCBIHuRef
CHM1_1240,269,776 - 40,669,965 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC8A1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731021
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.