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Gene: SLC8A1 (solute carrier family 8 member A1) Homo sapiens
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Symbol: SLC8A1
Name: solute carrier family 8 member A1
Description: Exhibits ankyrin binding activity and calcium:sodium antiporter activity. Involved in several processes, including cellular sodium ion homeostasis; metal ion transport; and positive regulation of the force of heart contraction. Localizes to the integral component of plasma membrane and nucleoplasm. Implicated in hypertension. Biomarker of Alzheimer's disease and pulmonary hypertension.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp779F0871; FLJ37694; FLJ43417; MGC119581; Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; NCX1; sodium/calcium exchanger 1; solute carrier family 8 (sodium/calcium exchanger), member 1; solute carrier family 8 member 1
Orthologs:
Mus musculus (house mouse) : Slc8a1 (solute carrier family 8 (sodium/calcium exchanger), member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc8a1 (solute carrier family 8 member A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc8a1 (solute carrier family 8 member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC8A1 (solute carrier family 8 member A1)
Canis lupus familiaris (dog) : SLC8A1 (solute carrier family 8 member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc8a1 (solute carrier family 8 member A1)
Sus scrofa (pig) : SLC8A1 (solute carrier family 8 member A1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38240,094,523 - 40,512,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37240,339,286 - 40,739,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36240,192,790 - 40,510,948 (-)NCBINCBI36hg18NCBI36
Build 34240,253,795 - 40,569,095NCBI
Celera240,180,223 - 40,580,364 (-)NCBI
Cytogenetic Map2p22.1NCBI
HuRef240,078,719 - 40,478,536 (-)NCBIHuRef
CHM1_1240,269,776 - 40,669,965 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC8A1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731021
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.