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Gene: DFFB (DNA fragmentation factor subunit beta) Homo sapiens
Symbol: DFFB
Name: DNA fragmentation factor subunit beta
Description: Exhibits several functions, including deoxyribonuclease activity; disordered domain specific binding activity; and identical protein binding activity. Involved in apoptotic DNA fragmentation; apoptotic chromosome condensation; and protein homooligomerization. Localizes to the cytosol and nuclear lumen.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAD; caspase-activated deoxyribonuclease; caspase-activated DNase; caspase-activated nuclease; CPAN; DFF-40; DFF2; DFF40; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
Mus musculus (house mouse) : Dffb (DNA fragmentation factor, beta subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dffb (DNA fragmentation factor subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dffb (DNA fragmentation factor subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : DFFB (DNA fragmentation factor subunit beta)
Canis lupus familiaris (dog) : DFFB (DNA fragmentation factor subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dffb (DNA fragmentation factor subunit beta)
Sus scrofa (pig) : DFFB (DNA fragmentation factor subunit beta)
more info ...
Related Pseudogenes: DFFBP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3813,857,267 - 3,885,429 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713,773,845 - 3,801,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613,763,705 - 3,791,853 (+)NCBINCBI36hg18NCBI36
Build 3413,797,001 - 3,825,149NCBI
Celera13,028,085 - 3,056,136 (+)NCBI
Cytogenetic Map1p36.32NCBI
HuRef13,069,403 - 3,097,689 (+)NCBIHuRef
CHM1_113,760,834 - 3,789,006 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DFFB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731033
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.