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Gene: Dffb (DNA fragmentation factor, beta subunit) Mus musculus
Symbol: Dffb
Name: DNA fragmentation factor, beta subunit
Description: Exhibits DNA binding activity and nuclease activity. Predicted to be involved in apoptotic DNA fragmentation; apoptotic chromosome condensation; and protein homooligomerization. Predicted to localize to the cytosol and nuclear lumen. Orthologous to human DFFB (DNA fragmentation factor subunit beta); PARTICIPATES IN apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 40kDa; 5730477D02Rik; CAD; caspase-activated deoxyribonuclease; caspase-activated DNase; CPAN; DFF-40; DFF40; Didff; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor subunit beta; DNA fragmentation factor, 40 kD, beta subunit; DNase inhibited by DNA fragmentation factor
Homo sapiens (human) : DFFB (DNA fragmentation factor subunit beta)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dffb (DNA fragmentation factor subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dffb (DNA fragmentation factor subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : DFFB (DNA fragmentation factor subunit beta)
Canis lupus familiaris (dog) : DFFB (DNA fragmentation factor subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dffb (DNA fragmentation factor subunit beta)
Sus scrofa (pig) : DFFB (DNA fragmentation factor subunit beta)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm384153,964,447 - 153,975,121 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374153,338,558 - 153,349,190 (-)NCBIGRCm37mm9NCBIm37
MGSCv364152,808,255 - 152,818,926 (-)NCBImm8
Celera4156,252,603 - 156,263,261 (-)NCBICelera
Cytogenetic Map4 E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dffb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731034
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.