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Gene: SPARC (secreted protein acidic and cysteine rich) Homo sapiens
Symbol: SPARC
Name: secreted protein acidic and cysteine rich
Description: Exhibits calcium ion binding activity and collagen binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; and positive regulation of endothelial cell migration. Localizes to the cell surface; nuclear matrix; and platelet alpha granule membrane. Implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Biomarker of calcinosis; ovary epithelial cancer; renal cell carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basement-membrane protein 40; BM-40; cysteine-rich protein; OI17; ON; ONT; osteonectin; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)
Mus musculus (house mouse) : Sparc (secreted acidic cysteine rich glycoprotein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sparc (secreted protein acidic and cysteine rich)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sparc (secreted protein acidic and cysteine rich)
Pan paniscus (bonobo/pygmy chimpanzee) : SPARC (secreted protein acidic and cysteine rich)
Canis lupus familiaris (dog) : SPARC (secreted protein acidic and cysteine rich)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sparc (secreted protein acidic and cysteine rich)
Sus scrofa (pig) : SPARC (secreted protein acidic and cysteine rich)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385151,661,096 - 151,686,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375151,040,657 - 151,066,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,021,201 - 151,046,710 (-)NCBINCBI36hg18NCBI36
Build 345151,021,203 - 151,046,710NCBI
Celera5147,122,406 - 147,147,929 (-)NCBI
Cytogenetic Map5q33.1NCBI
HuRef5146,186,043 - 146,212,010 (-)NCBIHuRef
CHM1_15150,473,070 - 150,499,042 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPARC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731035
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-12-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.