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Gene: GRK2 (G protein-coupled receptor kinase 2) Homo sapiens
Symbol: GRK2
Name: G protein-coupled receptor kinase 2
CRRD ID: 731036
Description: Exhibits Edg-2 lysophosphatidic acid receptor binding activity. Involved in several processes, including negative regulation of the force of heart contraction by chemical signal; regulation of muscle system process; and tachykinin receptor signaling pathway. Localizes to cytoplasm. Biomarker of congestive heart failure; liver cirrhosis; pituitary adenoma; and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADRBK1; adrenergic beta receptor kinase 1; adrenergic, beta, receptor kinase 1; BARK1; beta-adrenergic receptor kinase 1; beta-ARK-1; BETA-ARK1; FLJ16718; G-protein coupled receptor kinase 2
Mus musculus (house mouse) : Grk2 (G protein-coupled receptor kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grk2 (G protein-coupled receptor kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk2 (G protein-coupled receptor kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK2 (G protein-coupled receptor kinase 2)
Canis lupus familiaris (dog) : GRK2 (G protein-coupled receptor kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk2 (G protein-coupled receptor kinase 2)
Sus scrofa (pig) : GRK2 (G protein-coupled receptor kinase 2)
Chlorocebus sabaeus (African green monkey) : GRK2 (G protein-coupled receptor kinase 2)
Heterocephalus glaber (naked mole-rat) : Grk2 (G protein-coupled receptor kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1167,266,473 - 67,286,556 (+)EnsemblGRCh38hg38GRCh38
GRCh381167,266,420 - 67,286,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371167,033,905 - 67,054,029 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,790,481 - 66,810,605 (+)NCBINCBI36hg18NCBI36
Build 341166,790,668 - 66,810,945NCBI
Celera1164,377,313 - 64,386,599 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1163,362,803 - 63,382,690 (+)NCBIHuRef
CHM1_11166,912,110 - 66,937,037 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GRK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731036
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.