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Gene: EPHX2 (epoxide hydrolase 2) Homo sapiens
Symbol: EPHX2
Name: epoxide hydrolase 2
Description: Exhibits several functions, including magnesium ion binding activity; phosphatase activity; and protein homodimerization activity. Involved in several processes, including cholesterol homeostasis; phospholipid dephosphorylation; and stilbene catabolic process. Localizes to cytosol and peroxisome. Implicated in coronary artery disease; familial hypercholesterolemia; and hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABHD20; bifunctional epoxide hydrolase 2; CEH; cytosolic epoxide hydrolase; epoxide hydratase; epoxide hydrolase 2, cytoplasmic; epoxide hydrolase 2, cytosolic; epoxide hydrolase, soluble; SEH; soluble epoxide hydrolase
Mus musculus (house mouse) : Ephx2 (epoxide hydrolase 2, cytoplasmic)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ephx2 (epoxide hydrolase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ephx2 (epoxide hydrolase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHX2 (epoxide hydrolase 2)
Canis lupus familiaris (dog) : EPHX2 (epoxide hydrolase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ephx2 (epoxide hydrolase 2)
Sus scrofa (pig) : EPHX2 (epoxide hydrolase 2)
Chlorocebus sabaeus (African green monkey) : EPHX2 (epoxide hydrolase 2)
Heterocephalus glaber (naked mole-rat) : Ephx2 (epoxide hydrolase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl827,490,781 - 27,545,564 (+)EnsemblGRCh38hg38GRCh38
GRCh38827,491,143 - 27,597,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,348,519 - 27,402,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,404,562 - 27,458,403 (+)NCBINCBI36hg18NCBI36
Build 34827,404,561 - 27,458,403NCBI
Celera826,308,750 - 26,362,585 (+)NCBI
Cytogenetic Map8p21.2-p21.1NCBI
HuRef825,893,566 - 25,947,482 (+)NCBIHuRef
CHM1_1827,550,382 - 27,604,304 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EPHX2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731054
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.