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Gene: INS (insulin) Homo sapiens
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Symbol: INS
Name: insulin
CRRD ID: 731056
Description: Exhibits identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of inflammatory response; positive regulation of cell communication; and regulation of generation of precursor metabolites and energy. Localizes to extracellular space. Implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Biomarker of several diseases, including diabetes mellitus (multiple); fatty liver disease; hyperuricemia; osteoarthritis; and pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IDDM; IDDM1; IDDM2; ILPR; insulin-dependent diabetes mellitus 2; IRDN; MODY10; PNDM4; preproinsulin; proinsulin
Orthologs:
Mus musculus (house mouse) : Ins2 (insulin II)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ins2 (insulin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ins (insulin)
Pan paniscus (bonobo/pygmy chimpanzee) : INS (insulin)
Canis lupus familiaris (dog) : INS (insulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ins (insulin)
Sus scrofa (pig) : INS (insulin)
Chlorocebus sabaeus (African green monkey) : INS (insulin)
Heterocephalus glaber (naked mole-rat) : Ins (insulin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,159,779 - 2,161,341 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl112,159,779 - 2,161,221 (-)EnsemblGRCh38hg38GRCh38
GRCh38112,159,779 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,181,009 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,137,585 - 2,139,015 (-)NCBINCBI36hg18NCBI36
Build 34112,137,584 - 2,139,000NCBI
Celera112,217,516 - 2,218,946 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,971,272 - 1,972,702 (-)NCBIHuRef
CHM1_1112,179,957 - 2,181,387 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on INS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731056
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.