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Gene: Chrm1 (cholinergic receptor, muscarinic 1, CNS) Mus musculus
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Symbol: Chrm1
Name: cholinergic receptor, muscarinic 1, CNS
Description: Exhibits neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Involved in regulation of locomotion. Localizes to Schaffer collateral - CA1 synapse; cholinergic synapse; and integral component of postsynaptic membrane. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Is expressed in central nervous system; retina; and urinary system. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 1D-myo-inositol 1,4,5-trisphosphate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AChR M1; Chrm-1; M1; m1 muscarinic acetylcholine receptor protein; M1R; muscarinic acetylcholine receptor 1; muscarinic acetylcholine receptor M1
Orthologs:
Homo sapiens (human) : CHRM1 (cholinergic receptor muscarinic 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrm1 (cholinergic receptor, muscarinic 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm1 (cholinergic receptor muscarinic 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM1 (cholinergic receptor muscarinic 1)
Canis lupus familiaris (dog) : CHRM1 (cholinergic receptor muscarinic 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm1 (cholinergic receptor muscarinic 1)
Sus scrofa (pig) : CHRM1 (cholinergic receptor muscarinic 1)
Chlorocebus sabaeus (African green monkey) : CHRM1 (cholinergic receptor muscarinic 1)
Heterocephalus glaber (naked mole-rat) : Chrm1 (cholinergic receptor muscarinic 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl198,663,789 - 8,683,587 (+)EnsemblGRCm38mm10GRCm38
GRCm38198,664,005 - 8,683,606 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37198,738,495 - 8,758,096 (+)NCBIGRCm37mm9NCBIm37
MGSCv36198,723,372 - 8,748,612 (+)NCBImm8
Celera198,422,264 - 8,441,868 (+)NCBICelera
Cytogenetic Map19ANCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Chrm1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731069
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-05-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.