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Gene: GNAO1 (G protein subunit alpha o1) Homo sapiens
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Symbol: GNAO1
Name: G protein subunit alpha o1
Description: Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and dopamine receptor signaling pathway. Predicted to localize to the heterotrimeric G-protein complex. Implicated in early infantile epileptic encephalopathy 17.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686O0962; EIEE17; G-ALPHA-o; GNAO; GO2-q chimeric G-protein; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha activating polypeptide O; guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2; HLA-DQB1; NEDIM
Orthologs:
Mus musculus (house mouse) : Gnao1 (guanine nucleotide binding protein, alpha O)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gnao1 (G protein subunit alpha o1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnao1 (G protein subunit alpha o1)
Pan paniscus (bonobo/pygmy chimpanzee) : GNAO1 (G protein subunit alpha o1)
Canis lupus familiaris (dog) : GNAO1 (G protein subunit alpha o1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnao1 (G protein subunit alpha o1)
Sus scrofa (pig) : GNAO1 (G protein subunit alpha o1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,191,489 - 56,357,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371656,225,251 - 56,391,356 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,783,649 - 54,948,651 (+)NCBINCBI36hg18NCBI36
Build 341654,783,648 - 54,935,363NCBI
Celera1640,722,067 - 40,888,176 (+)NCBI
Cytogenetic Map16q13NCBI
HuRef1642,096,140 - 42,261,995 (+)NCBIHuRef
CHM1_11657,632,612 - 57,798,711 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GNAO1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731076
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.