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Gene: GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) Homo sapiens
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Symbol: GRIN2B
Name: glutamate ionotropic receptor NMDA type subunit 2B
CRRD ID: 731079
Description: Exhibits NMDA glutamate receptor activity; glutamate-gated calcium ion channel activity; and glycine binding activity. Involved in calcium ion transmembrane import into cytosol and response to ethanol. Localizes to NMDA selective glutamate receptor complex. Implicated in several diseases, including alcohol use disorder; autosomal dominant non-syndromic intellectual disability 6; bipolar disorder; early infantile epileptic encephalopathy 27; and neurodegenerative disease (multiple). Biomarker of Alzheimer's disease; temporal lobe epilepsy; and vascular dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DEE27; EIEE27; GluN2B; glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; hNR3; MGC142178; MGC142180; MRD6; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NR2B; NR3
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1213,437,942 - 13,982,002 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1213,437,942 - 13,981,957 (-)EnsemblGRCh38hg38GRCh38
GRCh381213,537,337 - 13,982,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371213,713,684 - 14,133,022 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361213,605,411 - 14,024,319 (-)NCBINCBI36hg18NCBI36
Build 341213,605,410 - 14,024,319NCBI
Celera1218,858,978 - 19,277,660 (-)NCBI
Cytogenetic Map12p13.1NCBI
HuRef1213,479,858 - 13,898,402 (-)NCBIHuRef
CHM1_11213,679,406 - 14,098,101 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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