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Gene: HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) Homo sapiens
Symbol: HSD17B4
Name: hydroxysteroid 17-beta dehydrogenase 4
Description: Exhibits long-chain-enoyl-CoA hydratase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in cellular hormone metabolic process; fatty acid beta-oxidation; and fatty-acyl-CoA metabolic process. Localizes to the peroxisome. Implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 17beta-estradiol dehydrogenase type IV; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; beta-hydroxyacyl dehydrogenase; beta-keto-reductase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein, peroxisomal; DBP; hydroxysteroid (17-beta) dehydrogenase 4; hydroxysteroid dehydrogenase 4; MFE-2; MPF-2; multifunctional protein 2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional enzyme type ii; peroxisomal multifunctional protein 2; PRLTS1; SDR8C1; short chain dehydrogenase/reductase family 8C member 1; short chain dehydrogenase/reductase family 8C, member 1
Mus musculus (house mouse) : Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Canis lupus familiaris (dog) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Sus scrofa (pig) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385119,452,497 - 119,542,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375118,788,138 - 118,878,030 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365118,816,122 - 118,905,923 (+)NCBINCBI36hg18NCBI36
Build 345118,816,123 - 118,905,923NCBI
Celera5114,741,869 - 114,831,759 (+)NCBI
Cytogenetic Map5q23.1NCBI
HuRef5113,983,371 - 114,073,268 (+)NCBIHuRef
CHM1_15118,221,090 - 118,311,127 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSD17B4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731284
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.