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Gene: ADRB1 (adrenoceptor beta 1) Homo sapiens
Symbol: ADRB1
Name: adrenoceptor beta 1
CRRD ID: 731289
Description: Exhibits several functions, including PDZ domain binding activity; alpha-2A adrenergic receptor binding activity; and protein heterodimerization activity. Involved in adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of GTPase activity; and regulation of circadian sleep/wake cycle, sleep. Localizes to early endosome and plasma membrane. Implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Biomarker of aortic valve stenosis and cystic fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADRB1R; adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; B1AR; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; BETA1AR; FNSS2; RHR
Mus musculus (house mouse) : Adrb1 (adrenergic receptor, beta 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adrb1 (adrenoceptor beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adrb1 (adrenoceptor beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRB1 (adrenoceptor beta 1)
Canis lupus familiaris (dog) : ADRB1 (adrenoceptor beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adrb1 (adrenoceptor beta 1)
Sus scrofa (pig) : ADRB1 (adrenoceptor beta 1)
Chlorocebus sabaeus (African green monkey) : ADRB1 (adrenoceptor beta 1)
Heterocephalus glaber (naked mole-rat) : Adrb1 (adrenoceptor beta 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl10114,043,866 - 114,046,904 (+)EnsemblGRCh38hg38GRCh38
GRCh3810114,043,866 - 114,046,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710115,803,806 - 115,806,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,793,796 - 115,796,657 (+)NCBINCBI36hg18NCBI36
Build 3410115,793,804 - 115,795,518NCBI
Celera10109,531,177 - 109,534,039 (+)NCBI
Cytogenetic Map10q25.3ENTREZGENE
HuRef10109,429,477 - 109,432,333 (+)NCBIHuRef
CHM1_110116,087,711 - 116,090,573 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ADRB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731289
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.