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Gene: ADRB1 (adrenoceptor beta 1) Homo sapiens
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Symbol: ADRB1
Name: adrenoceptor beta 1
Description: Exhibits several functions, including PDZ domain binding activity; alpha-2A adrenergic receptor binding activity; and protein heterodimerization activity. Involved in adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of GTPase activity; and regulation of circadian sleep/wake cycle, sleep. Localizes to the early endosome and plasma membrane. Implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Biomarker of aortic valve stenosis and cystic fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADRB1R; adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; B1AR; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; BETA1AR; FNSS2; RHR
Orthologs:
Mus musculus (house mouse) : Adrb1 (adrenergic receptor, beta 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adrb1 (adrenoceptor beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adrb1 (adrenoceptor beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRB1 (adrenoceptor beta 1)
Canis lupus familiaris (dog) : ADRB1 (adrenoceptor beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adrb1 (adrenoceptor beta 1)
Sus scrofa (pig) : ADRB1 (adrenoceptor beta 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810114,043,866 - 114,046,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710115,803,806 - 115,806,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,793,796 - 115,796,657 (+)NCBINCBI36hg18NCBI36
Build 3410115,793,804 - 115,795,518NCBI
Celera10109,531,177 - 109,534,039 (+)NCBI
Cytogenetic Map10q25.3ENTREZGENE
HuRef10109,429,477 - 109,432,333 (+)NCBIHuRef
CHM1_110116,087,711 - 116,090,573 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ADRB1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731289
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.