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Gene: DUSP6 (dual specificity phosphatase 6) Homo sapiens
Symbol: DUSP6
Name: dual specificity phosphatase 6
CRRD ID: 731297
Description: Exhibits MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of MAPK cascade; peptidyl-tyrosine dephosphorylation; and response to nitrosative stress. Localizes to cytosol and nucleoplasm. Implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity protein phosphatase 6; dual specificity protein phosphatase PYST1; HH19; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; MKP3; PYST1; serine/threonine specific protein phosphatase
Mus musculus (house mouse) : Dusp6 (dual specificity phosphatase 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dusp6 (dual specificity phosphatase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp6 (dual specificity phosphatase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP6 (dual specificity phosphatase 6)
Canis lupus familiaris (dog) : DUSP6 (dual specificity phosphatase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp6 (dual specificity phosphatase 6)
Sus scrofa (pig) : DUSP6 (dual specificity phosphatase 6)
Chlorocebus sabaeus (African green monkey) : DUSP6 (dual specificity phosphatase 6)
Heterocephalus glaber (naked mole-rat) : Dusp6 (dual specificity phosphatase 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1289,347,235 - 89,352,501 (-)EnsemblGRCh38hg38GRCh38
GRCh381289,347,235 - 89,352,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371289,741,837 - 89,746,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361288,265,968 - 88,270,427 (-)NCBINCBI36hg18NCBI36
Build 341288,244,306 - 88,248,764NCBI
Celera1289,413,532 - 89,417,991 (-)NCBI
Cytogenetic Map12q21.33NCBI
HuRef1286,807,701 - 86,812,160 (-)NCBIHuRef
CHM1_11289,706,555 - 89,711,589 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DUSP6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731297
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.