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Gene: Dusp6 (dual specificity phosphatase 6) Mus musculus
Symbol: Dusp6
Name: dual specificity phosphatase 6
Description: Exhibits phosphoprotein phosphatase activity. Involved in negative regulation of protein phosphorylation; protein dephosphorylation; and regulation of heart growth. Predicted to localize to the cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; renal cortex; and sensory organ. Orthologous to human DUSP6 (dual specificity phosphatase 6); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1300019I03Rik; dual specificity protein phosphatase 6; MAP kinase phosphatase 3; MGC98540; mitogen-activated protein kinase phosphatase 3; MKP-3; MKP3; PYST1
Homo sapiens (human) : DUSP6 (dual specificity phosphatase 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dusp6 (dual specificity phosphatase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp6 (dual specificity phosphatase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP6 (dual specificity phosphatase 6)
Canis lupus familiaris (dog) : DUSP6 (dual specificity phosphatase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp6 (dual specificity phosphatase 6)
Sus scrofa (pig) : DUSP6 (dual specificity phosphatase 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381099,263,231 - 99,267,489 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371098,725,865 - 98,730,123 (+)NCBIGRCm37mm9NCBIm37
MGSCv361098,692,919 - 98,697,172 (+)NCBImm8
Celera10101,235,116 - 101,239,374 (+)NCBICelera
Cytogenetic Map10 D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dusp6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731298
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.