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Gene: Adam17 (a disintegrin and metallopeptidase domain 17) Mus musculus
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Symbol: Adam17
Name: a disintegrin and metallopeptidase domain 17
Description: Exhibits endopeptidase activity and metallopeptidase activity. Involved in several processes, including PMA-inducible membrane protein ectodomain proteolysis; hematopoietic or lymphoid organ development; and regulation of neurogenesis. Localizes to the cytoplasm and membrane. Predicted to colocalize with the cell-cell junction; focal adhesion; and ruffle membrane. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Is expressed in brain; foregut-midgut junction; heart; and lung. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17; ADAM 17; CD156b; disintegrin and metalloproteinase domain-containing protein 17; Tace; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
Orthologs:
Homo sapiens (human) : ADAM17 (ADAM metallopeptidase domain 17)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Adam17 (ADAM metallopeptidase domain 17)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam17 (ADAM metallopeptidase domain 17)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM17 (ADAM metallopeptidase domain 17)
Canis lupus familiaris (dog) : ADAM17 (ADAM metallopeptidase domain 17)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam17 (ADAM metallopeptidase domain 17)
Sus scrofa (pig) : ADAM17 (ADAM metallopeptidase domain 17)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381221,323,509 - 21,373,632 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371221,329,370 - 21,379,452 (-)NCBIGRCm37mm9NCBIm37
MGSCv361221,570,005 - 21,620,083 (-)NCBImm8
Celera1219,527,926 - 19,579,463 (+)NCBICelera
Cytogenetic Map12 A1.3NCBI
cM Map128.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Adam17
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731401
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.