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Gene: Sh2b1 (SH2B adaptor protein 1) Mus musculus
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Symbol: Sh2b1
Name: SH2B adaptor protein 1
Description: Predicted to have transmembrane receptor protein tyrosine kinase adaptor activity. Involved in lamellipodium assembly; positive regulation of mitotic nuclear division; and regulation of DNA biosynthetic process. Predicted to localize to the plasma membrane. Is expressed in dorsal aorta. Orthologous to human SH2B1 (SH2B adaptor protein 1); PARTICIPATES IN leptin system pathway; neurotrophic factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI425885; C530001K22Rik; Irip; mKIAA1299; pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B; SH2-B; SH2-B PH domain containing signaling mediator 1; SH2-B PH domain-containing signaling mediator 1; SH2-Bb; SH2B adapter protein 1; Sh2bpsm1
Orthologs:
Homo sapiens (human) : SH2B1 (SH2B adaptor protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sh2b1 (SH2B adaptor protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b1 (SH2B adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B1 (SH2B adaptor protein 1)
Canis lupus familiaris (dog) : SH2B1 (SH2B adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b1 (SH2B adaptor protein 1)
Sus scrofa (pig) : SH2B1 (SH2B adaptor protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm387126,466,993 - 126,476,650 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377133,610,508 - 133,618,644 (-)NCBIGRCm37mm9NCBIm37
MGSCv367126,258,144 - 126,264,159 (-)NCBImm8
Celera7126,319,558 - 126,327,690 (-)NCBICelera
Cytogenetic Map7 F3NCBI
cM Map769.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Sh2b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731403
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.