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Gene: Sh2b1 (SH2B adaptor protein 1) Mus musculus
Symbol: Sh2b1
Name: SH2B adaptor protein 1
Description: Predicted to have transmembrane receptor protein tyrosine kinase adaptor activity. Involved in lamellipodium assembly; positive regulation of mitotic nuclear division; and regulation of DNA biosynthetic process. Predicted to localize to the plasma membrane. Is expressed in dorsal aorta. Orthologous to human SH2B1 (SH2B adaptor protein 1); PARTICIPATES IN leptin system pathway; neurotrophic factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI425885; C530001K22Rik; Irip; mKIAA1299; pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B; SH2-B; SH2-B PH domain containing signaling mediator 1; SH2-B PH domain-containing signaling mediator 1; SH2-Bb; SH2B adapter protein 1; Sh2bpsm1
Homo sapiens (human) : SH2B1 (SH2B adaptor protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sh2b1 (SH2B adaptor protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b1 (SH2B adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B1 (SH2B adaptor protein 1)
Canis lupus familiaris (dog) : SH2B1 (SH2B adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b1 (SH2B adaptor protein 1)
Sus scrofa (pig) : SH2B1 (SH2B adaptor protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm387126,466,993 - 126,476,650 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377133,610,508 - 133,618,644 (-)NCBIGRCm37mm9NCBIm37
MGSCv367126,258,144 - 126,264,159 (-)NCBImm8
Celera7126,319,558 - 126,327,690 (-)NCBICelera
Cytogenetic Map7 F3NCBI
cM Map769.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sh2b1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731403
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.