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Gene: RAPGEF1 (Rap guanine nucleotide exchange factor 1) Homo sapiens
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Symbol: RAPGEF1
Name: Rap guanine nucleotide exchange factor 1
Description: Exhibits Rap guanyl-nucleotide exchange factor activity. Involved in several processes, including Rap protein signal transduction; cellular response to cAMP; and nerve growth factor signaling pathway. Localizes to the early endosome and intracellular membrane-bounded organelle.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C3G; CRK SH3-binding GNRP; DKFZp781P1719; GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene); Rap guanine nucleotide exchange factor (GEF) 1
Orthologs:
Mus musculus (house mouse) : Rapgef1 (Rap guanine nucleotide exchange factor (GEF) 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rapgef1 (Rap guanine nucleotide exchange factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef1 (Rap guanine nucleotide exchange factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
Canis lupus familiaris (dog) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef1 (Rap guanine nucleotide exchange factor 1)
Sus scrofa (pig) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
Chlorocebus sabaeus (African green monkey) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
Heterocephalus glaber (naked mole-rat) : Rapgef1 (Rap guanine nucleotide exchange factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl9131,576,770 - 131,740,074 (-)Ensembl
GRCh389131,576,770 - 131,740,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379134,452,157 - 134,615,364 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369133,441,978 - 133,602,746 (-)NCBINCBI36hg18NCBI36
Celera9104,992,289 - 105,153,075 (-)NCBI
Cytogenetic Map9q34.13NCBI
HuRef9103,946,113 - 104,106,918 (-)NCBIHuRef
CHM1_19134,601,537 - 134,764,677 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on RAPGEF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731405
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.