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Gene: Il6st (interleukin 6 signal transducer) Mus musculus
Symbol: Il6st
Name: interleukin 6 signal transducer
Description: Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Localizes to the dendrite; external side of plasma membrane; and neuronal cell body. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis and hyperandrogenism. Is expressed in several structures, including bone marrow; early conceptus; female reproductive system; gonad; and nervous system. Orthologous to human IL6ST (interleukin 6 signal transducer); PARTICIPATES IN interleukin-27 signaling pathway; interleukin-6 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-octadec-9-enoylglycero-3-phosphate; 2,3,7,8-tetrachlorodibenzodioxine; 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699e; gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; interleukin-6 receptor subunit beta; interleukin-6 signal transducer; membrane glycoprotein 130; oncostatin-M receptor subunit alpha
Homo sapiens (human) : IL6ST (interleukin 6 signal transducer)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il6st (interleukin 6 signal transducer)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il6st (interleukin 6 signal transducer)
Pan paniscus (bonobo/pygmy chimpanzee) : IL6ST (interleukin 6 signal transducer)
Canis lupus familiaris (dog) : IL6ST (interleukin 6 signal transducer)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il6st (interleukin 6 signal transducer)
Sus scrofa (pig) : IL6ST (interleukin 6 signal transducer)
Chlorocebus sabaeus (green monkey) : IL6ST (interleukin 6 signal transducer)
Heterocephalus glaber (naked mole-rat) : Il6st (interleukin 6 signal transducer)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl13112,464,070 - 112,510,086 (+)Ensembl
GRCm3813112,464,070 - 112,506,860 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3713113,254,278 - 113,297,068 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613113,584,987 - 113,627,719 (+)NCBImm8
Celera13116,768,393 - 116,811,051 (+)NCBICelera
Cytogenetic Map13 D2.2NCBI
cM Map1363.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il6st
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731410
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.