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Gene: Timp1 (tissue inhibitor of metalloproteinase 1) Mus musculus
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Description: Predicted to have molecular function regulator; protease binding activity; and zinc ion binding activity. Involved in connective tissue replacement involved in inflammatory response wound healing. Localizes to basement membrane. Is expressed in several structures, including early conceptus; hindlimb cartilage condensation; jaw; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1); PARTICIPATES IN interleukin-6 signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid; 1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cl; Clgi; collagenase inhibitor 16C8 fibroblast; EPA; erythroid-potentiating activity; metalloproteinase inhibitor 1; MGC7143; Timp; TIMP-1; tissue inhibitor of metalloproteinase-1; tissue inhibitor of metalloproteinases 1; TPA-induced protein; TPA-S1
Homo sapiens (human) : TIMP1 (TIMP metallopeptidase inhibitor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Timp1 (TIMP metallopeptidase inhibitor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp1 (TIMP metallopeptidase inhibitor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP1 (TIMP metallopeptidase inhibitor 1)
Canis lupus familiaris (dog) : TIMP1 (TIMP metallopeptidase inhibitor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp1 (TIMP metallopeptidase inhibitor 1)
Sus scrofa (pig) : TIMP1 (TIMP metallopeptidase inhibitor 1)
Chlorocebus sabaeus (African green monkey) : TIMP1 (TIMP metallopeptidase inhibitor 1)
Heterocephalus glaber (naked mole-rat) : Timp1 (TIMP metallopeptidase inhibitor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBImm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Timp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731433
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.