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Gene: Dab2 (disabled 2, mitogen-responsive phosphoprotein) Mus musculus
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Symbol: Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Description: Exhibits several functions, including AP-2 adaptor complex binding activity; clathrin adaptor activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endocytosis; hemopoiesis; and positive regulation of macromolecule metabolic process. Localizes to apical plasma membrane; clathrin coat of coated pit; and nucleus. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; future hindbrain roof plate; and metanephros. Orthologous to human DAB2 (DAB adaptor protein 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; INTERACTS WITH 1,2-dichloroethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730435J12Rik; AA960054; adaptor molecule disabled-2; AI957090; D15Wsu122e; D630005B22Rik; differentially expressed in ovarian carcinoma 2; disabled homolog 2; Doc-2; Doc2; mitogen-responsive phosphoprotein; p96; RIKEN cDNA D630005B22 gene
Orthologs:
Homo sapiens (human) : DAB2 (DAB adaptor protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dab2 (DAB adaptor protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dab2 (DAB adaptor protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DAB2 (DAB adaptor protein 2)
Canis lupus familiaris (dog) : DAB2 (DAB adaptor protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dab2 (DAB adaptor protein 2)
Sus scrofa (pig) : DAB2 (DAB adaptor protein 2)
Chlorocebus sabaeus (African green monkey) : DAB2 (DAB adaptor protein 2)
Heterocephalus glaber (naked mole-rat) : Dab2 (DAB adaptor protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl156,299,788 - 6,440,712 (+)EnsemblGRCm38mm10GRCm38
GRCm38156,299,788 - 6,440,715 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37156,249,789 - 6,390,712 (+)NCBIGRCm37mm9NCBIm37
MGSCv36156,247,064 - 6,387,927 (+)NCBImm8
Celera156,148,799 - 6,289,867 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map152.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Dab2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731452
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.