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Gene: PRDX4 (peroxiredoxin 4) Homo sapiens
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Symbol: PRDX4
Name: peroxiredoxin 4
Description: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antioxidant enzyme AOE372; AOE37-2; AOE372; epididymis secretory sperm binding protein Li 97n; HEL-S-97n; peroxiredoxin IV; peroxiredoxin-4; PRX-4; prx-IV; thioredoxin peroxidase (antioxidant enzyme); thioredoxin peroxidase AO372; thioredoxin-dependent peroxide reductase A0372
Orthologs:
Mus musculus (house mouse) : Prdx4 (peroxiredoxin 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prdx4 (peroxiredoxin 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prdx4 (peroxiredoxin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PRDX4 (peroxiredoxin 4)
Canis lupus familiaris (dog) : PRDX4 (peroxiredoxin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prdx4 (peroxiredoxin 4)
Sus scrofa (pig) : PRDX4 (peroxiredoxin 4)
more info ...
Related Pseudogenes: PRDX4P1   PRDX4P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X23,664,260 - 23,686,399 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X23,682,377 - 23,704,516 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X23,595,566 - 23,614,435 (+)NCBINCBI36hg18NCBI36
Build 34X23,445,301 - 23,464,171NCBI
CeleraX27,807,255 - 27,826,109 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX21,425,714 - 21,444,033 (+)NCBIHuRef
CHM1_1X23,716,633 - 23,735,478 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PRDX4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731497
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.