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Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha) Mus musculus
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Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Description: Predicted to have ribosome binding activity and translation initiation factor activity. Involved in several processes, including cellular protein metabolic process; negative regulation of translational initiation in response to stress; and stress granule assembly. Localizes to the cytoplasmic stress granule; nucleus; and synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha); PARTICIPATES IN translation initiation pathway; Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 0910001O23Rik; 2410026C18Rik; 35kDa; eIF-2-alpha; eIF-2A; eIF-2alpha; Eif2a; eIF2alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2A
Orthologs:
Related Pseudogenes: Gm12734   Gm13915   Gm7459  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1278,861,819 - 78,887,010 (+)Ensembl
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIGRCm37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBImm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12 C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Eif2s1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731513
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.