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Gene: AFDN (afadin, adherens junction formation factor) Homo sapiens
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Symbol: AFDN
Name: afadin, adherens junction formation factor
Description: Exhibits Ras GTPase binding activity and actin filament binding activity. Involved in several processes, including bicellular tight junction assembly; establishment of endothelial intestinal barrier; and positive regulation of cell-cell adhesion mediated by cadherin. Localizes to several cellular components, including the cell-cell contact zone; nuclear speck; and pore complex. Biomarker of Parkinson's disease and breast carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AF-6; AF6; afadin; ALL1-fused gene from chromosome 6 protein; FLJ34371; l-afadin; MLL-AF6; MLLT4; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); RP3-431P23.3; translocated to, 4
Orthologs:
Mus musculus (house mouse) : Afdn (afadin, adherens junction formation factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Afdn (afadin, adherens junction formation factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afdn (afadin, adherens junction formation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : AFDN (afadin, adherens junction formation factor)
Canis lupus familiaris (dog) : AFDN (afadin, adherens junction formation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afdn (afadin, adherens junction formation factor)
Sus scrofa (pig) : AFDN (afadin, adherens junction formation factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386167,826,564 - 167,972,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376168,227,602 - 168,372,703 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366167,970,520 - 168,115,552 (+)NCBINCBI36hg18NCBI36
Build 346168,046,368 - 168,171,498NCBI
Celera6168,944,733 - 169,081,690 (+)NCBI
Cytogenetic Map6q27NCBI
HuRef6165,693,043 - 165,800,385 (+)NCBIHuRef
CHM1_16168,490,726 - 168,635,428 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AFDN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731514
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.