Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: NRG1 (neuregulin 1) Homo sapiens
Symbol: NRG1
Name: neuregulin 1
CRRD ID: 731515
Description: Exhibits molecular function regulator and signaling receptor binding activity. Involved in several processes, including ERBB signaling pathway; heart development; and positive regulation of protein phosphorylation. Localizes to several cellular components, including apical plasma membrane; glutamatergic synapse; and integral component of synaptic membrane. Implicated in Charcot-Marie-Tooth disease; dementia; middle cerebral artery infarction; myocardial infarction; and psychotic disorder (multiple). Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acetylcholine receptor-inducing activity; ARIA; GGF; GGF2; glial growth factor; glial growth factor 2; heregulin, alpha (45kD, ERBB2 p185-activator); HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; neu differentiation factor; neuregulin 1 type IV beta 1a; neuregulin 1 type IV beta 3; NRG1 intronic transcript 2 (non-protein coding); NRG1-IT2; pro-neuregulin-1, membrane-bound isoform; pro-NRG1; sensory and motor neuron derived factor; SMDF
Mus musculus (house mouse) : Nrg1 (neuregulin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nrg1 (neuregulin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nrg1 (neuregulin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NRG1 (neuregulin 1)
Canis lupus familiaris (dog) : NRG1 (neuregulin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nrg1 (neuregulin 1)
Sus scrofa (pig) : NRG1 (neuregulin 1)
Chlorocebus sabaeus (African green monkey) : NRG1 (neuregulin 1)
Heterocephalus glaber (naked mole-rat) : Nrg1 (neuregulin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl831,639,222 - 32,855,666 (+)EnsemblGRCh38hg38GRCh38
GRCh38831,639,245 - 32,774,046 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37831,496,820 - 32,622,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36831,616,810 - 32,741,615 (+)NCBINCBI36hg18NCBI36
Build 34832,525,654 - 32,741,615NCBI
Celera830,430,833 - 31,581,276 (+)NCBI
Cytogenetic Map8p12NCBI
HuRef830,042,037 - 31,167,972 (+)NCBIHuRef
CHM1_1831,698,194 - 32,827,151 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences