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Gene: IL2RG (interleukin 2 receptor subunit gamma) Homo sapiens
Symbol: IL2RG
Name: interleukin 2 receptor subunit gamma
Description: Exhibits interleukin-15 receptor activity. Predicted to contribute to interleukin-2 receptor activity; interleukin-4 receptor activity; and interleukin-7 receptor activity. Involved in interleukin-15-mediated signaling pathway and positive regulation of phagocytosis. Localizes to cell surface. Implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Biomarker of COVID-19.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD132; CD132 antigen; CIDX; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; common gamma-chain; cytokine receptor common subunit gamma; gamma(c); gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IMD4; interleukin 2 receptor, gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); interleukin 2 receptor, gamma chain; interleukin-2 receptor subunit gamma; nonfunctional common cytokine receptor gamma chain; P64; SCIDX; SCIDX1; severe combined immunodeficiency
Mus musculus (house mouse) : Il2rg (interleukin 2 receptor, gamma chain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il2rg (interleukin 2 receptor subunit gamma)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2rg (interleukin 2 receptor subunit gamma)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2RG (interleukin 2 receptor subunit gamma)
Canis lupus familiaris (dog) : IL2RG (interleukin 2 receptor subunit gamma)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2rg (interleukin 2 receptor subunit gamma)
Sus scrofa (pig) : IL2RG (interleukin 2 receptor subunit gamma)
Chlorocebus sabaeus (African green monkey) : IL2RG (interleukin 2 receptor subunit gamma)
Heterocephalus glaber (naked mole-rat) : Il2rg (interleukin 2 receptor subunit gamma)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX71,107,404 - 71,112,108 (-)EnsemblGRCh38hg38GRCh38
GRCh38X71,107,404 - 71,111,577 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,327,254 - 70,331,481 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,243,984 - 70,248,128 (-)NCBINCBI36hg18NCBI36
Build 34X70,110,279 - 70,114,424NCBI
CeleraX70,681,159 - 70,685,386 (-)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,146,973 - 64,150,762 (-)NCBIHuRef
CHM1_1X70,219,589 - 70,223,820 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL2RG
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731533
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.