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Gene: IL2RG (interleukin 2 receptor subunit gamma) Homo sapiens
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Symbol: IL2RG
Name: interleukin 2 receptor subunit gamma
Description: The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD132; CD132 antigen; CIDX; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; common gamma-chain; cytokine receptor common subunit gamma; gamma(c); gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IMD4; interleukin 2 receptor, gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); interleukin 2 receptor, gamma chain; interleukin-2 receptor subunit gamma; nonfunctional common cytokine receptor gamma chain; P64; SCIDX; SCIDX1; severe combined immunodeficiency
Orthologs:
Mus musculus (house mouse) : Il2rg (interleukin 2 receptor, gamma chain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il2rg (interleukin 2 receptor subunit gamma)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2rg (interleukin 2 receptor subunit gamma)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2RG (interleukin 2 receptor subunit gamma)
Canis lupus familiaris (dog) : IL2RG (interleukin 2 receptor subunit gamma)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2rg (interleukin 2 receptor subunit gamma)
Sus scrofa (pig) : IL2RG (interleukin 2 receptor subunit gamma)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,107,404 - 71,111,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,327,254 - 70,331,481 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,243,984 - 70,248,128 (-)NCBINCBI36hg18NCBI36
Build 34X70,110,279 - 70,114,424NCBI
CeleraX70,681,159 - 70,685,386 (-)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,146,973 - 64,150,762 (-)NCBIHuRef
CHM1_1X70,219,589 - 70,223,820 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IL2RG
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731533
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.