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Gene: ASL (argininosuccinate lyase) Homo sapiens
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Symbol: ASL
Name: argininosuccinate lyase
Description: Exhibits identical protein binding activity. Predicted to be involved in arginine biosynthetic process via ornithine. Localizes to the extracellular exosome. Implicated in amino acid metabolic disorder and argininosuccinic aciduria. Biomarker of argininosuccinic aciduria and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: argininosuccinase; arginosuccinase; ASAL
Orthologs:
Mus musculus (house mouse) : Asl (argininosuccinate lyase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Asl (argininosuccinate lyase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Asl (argininosuccinate lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : ASL (argininosuccinate lyase)
Canis lupus familiaris (dog) : ASL (argininosuccinate lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Asl (argininosuccinate lyase)
Sus scrofa (pig) : ASL (argininosuccinate lyase)
more info ...
Related Pseudogenes: ASLP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38766,075,819 - 66,093,576 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37765,540,776 - 65,558,330 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36765,178,211 - 65,195,765 (+)NCBINCBI36hg18NCBI36
Build 34764,984,963 - 65,002,090NCBI
Celera766,555,388 - 66,572,941 (-)NCBI
Cytogenetic Map7q11.21ENTREZGENE
HuRef761,727,625 - 61,745,174 (+)NCBIHuRef
CHM1_1765,636,440 - 65,653,994 (+)NCBICHM1_1
CRA_TCAGchr7v2764,878,281 - 64,895,827 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ASL
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731559
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.