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Cellular Component
Molecular Function
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![]() Biological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | branching morphogenesis of an epithelial tube | | IEA | UniProtKB:Q9R1X4, ensembl:ENSMUSP00000058021 | 2290271 | | Ensembl | GO_REF:0000107 | cell cycle phase transition | | IMP | | 2290271 | (PMID:17102137) | BHF-UCL | PMID:17102137 | cell division | | IEA | UniProtKB-KW:KW-0132 | 2290271 | | UniProtKB | GO_REF:0000037 | cellular response to bleomycin | | IMP | | 2290271 | (PMID:23797032) | UniProtKB | PMID:23797032 | cellular response to cisplatin | | IMP | | 2290271 | (PMID:23797032) | UniProtKB | PMID:23797032 | cellular response to DNA damage stimulus | | IMP | | 2290271 | (PMID:23797032) | UniProtKB | PMID:23797032 | cellular response to DNA damage stimulus | | ISS | UniProtKB:Q9R1X4 | 2290271 | | UniProtKB | GO_REF:0000024 | cellular response to hydroxyurea | | IMP | | 2290271 | (PMID:23797032) | UniProtKB | PMID:23797032 | circadian rhythm | | ISS | UniProtKB:Q9R1X4 | 2290271 | | UniProtKB | GO_REF:0000024 | detection of abiotic stimulus | | TAS | | 2290271 | (PMID:9856466) | PINC | PMID:9856466 | DNA repair | | IBA | PANTHER:PTN000533813, SGD:S000005217 | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | DNA replication | | TAS | | 2290271 | | Reactome | Reactome:R-HSA-5684887 | DNA replication checkpoint | | IBA | PANTHER:PTN000533813 more ... | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | lung development | | IEA | UniProtKB:Q9R1X4, ensembl:ENSMUSP00000058021 | 2290271 | | Ensembl | GO_REF:0000107 | morphogenesis of an epithelium | | ISS | UniProtKB:Q9R1X4 | 2290271 | | UniProtKB | GO_REF:0000024 | negative regulation of transcription by RNA polymerase II | | IEA | UniProtKB:Q9R1X4, ensembl:ENSMUSP00000058021 | 2290271 | | Ensembl | GO_REF:0000107 | negative regulation of transcription, DNA-templated | | IDA | | 2290271 | (PMID:9856465) | UniProtKB | PMID:9856465 | positive regulation of double-strand break repair | | IMP | | 2290271 | (PMID:23797032) | UniProtKB | PMID:23797032 | positive regulation of double-strand break repair via homologous recombination | | IDA | | 2290271 | (PMID:26344098), (PMID:30356214) | UniProt | PMID:26344098, PMID:30356214 | regulation of cell population proliferation | NOT | IMP | | 2290271 | (PMID:17102137) | HGNC | PMID:17102137 | regulation of circadian rhythm | | IMP | | 2290271 | (PMID:23418588) | UniProtKB | PMID:23418588 | replication fork arrest | | IBA | PANTHER:PTN000533813 more ... | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | replication fork protection | | IBA | PANTHER:PTN000533813 more ... | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | |
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1. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
2. | RGD automated import pipeline for gene-chemical interactions |
PubMed | 9856465 9856466 9891984 10428031 11382904 12477932 12875843 14637143 14702039 14985107 15300647 15302935 15342556 15489334 15565336 15798197 15946665 16507006 16964243 17081983 17102137 17116885 17141802 17296725 17909269 18228528 18451105 19470168 19693801 19696745 19839995 19913121 19934327 19996108 20072116 20124417 20149345 20174623 20180986 20211142 20360068 20379614 20554694 20628086 20980603 21490103 21508667 21573113 21873635 21988832 22006848 22266860 22610502 22672906 22863883 22939629 23173913 23255133 23325691 23418588 23511638 23797032 24104479 24144296 24161199 24636202 24716566 25405317 25921289 26186194 26344098 26344197 26456830 26496610 27587400 27909716 28191891 28334766 28464854 28514442 28583847 28708003 29180619 29507755 29555554 29576527 30033366 30100061 30183357 30249891 30303954 30356214 30629587 30796221 |
TIMELESS (Homo sapiens - human) |
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Timeless (Mus musculus - house mouse) |
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Timeless (Rattus norvegicus - Norway rat) |
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Timeless (Chinchilla lanigera - long-tailed chinchilla) |
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TIMELESS (Pan paniscus - bonobo/pygmy chimpanzee) |
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TIMELESS (Canis lupus familiaris - dog) |
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Timeless (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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D12S1778 |
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TIMELESS_1103 |
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RH48818 |
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The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
RefSeq Transcripts | NM_001330295 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_003920 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NR_138471 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AB015597 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AC024884 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AF098162 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK000721 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK022702 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK296869 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AY207390 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC031514 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC039842 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC050557 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BE503292 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BP363571 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BX640990 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH471054 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU627094 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
HY040179 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_001330295 ⟹ NP_001317224 | |||||||||
RefSeq Status: | REVIEWED | |||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
AGTTCGCTCGGAGTCACGTGGACCAGCCCGGCTCGCCCCGCCTCGCTCTTCGCGCAGGCGGGGAhide sequence |
RefSeq Acc Id: | NM_003920 ⟹ NP_003911 | |||||||||||||||||||||||||||||
RefSeq Status: | REVIEWED | |||||||||||||||||||||||||||||
Type: | CODING | |||||||||||||||||||||||||||||
Position: |
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Sequence: |
AGTTCGCTCGGAGTCACGTGGACCAGCCCGGCTCGCCCCGCCTCGCTCTTCGCGCAGGCGGGGAhide sequence |
RefSeq Acc Id: | NR_138471 | |||||||||
RefSeq Status: | REVIEWED | |||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
AGTTCGCTCGGAGTCACGTGGACCAGCCCGGCTCGCCCCGCCTCGCTCTTCGCGCAGGCGGGGAhide sequence |
Protein RefSeqs | NP_001317224 | (Get FASTA) | NCBI Sequence Viewer |
NP_003911 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAC80011 | (Get FASTA) | NCBI Sequence Viewer |
AAH39842 | (Get FASTA) | NCBI Sequence Viewer | |
AAH50557 | (Get FASTA) | NCBI Sequence Viewer | |
ACD11488 | (Get FASTA) | NCBI Sequence Viewer | |
BAA36499 | (Get FASTA) | NCBI Sequence Viewer | |
BAG51106 | (Get FASTA) | NCBI Sequence Viewer | |
BAG59432 | (Get FASTA) | NCBI Sequence Viewer | |
CAE45996 | (Get FASTA) | NCBI Sequence Viewer | |
EAW96939 | (Get FASTA) | NCBI Sequence Viewer | |
Q9UNS1 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_003911 ⟸ NM_003920 |
- Peptide Label: | isoform 1 |
- UniProtKB: | Q9UNS1 (UniProtKB/Swiss-Prot) |
- Sequence: |
MDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDhide sequence |
RefSeq Acc Id: | NP_001317224 ⟸ NM_001330295 |
- Peptide Label: | isoform 2 |
- UniProtKB: | Q9UNS1 (UniProtKB/Swiss-Prot) |
- Sequence: |
MDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDhide sequence |
RGD ID: | 6790544 | |||||||||
Promoter ID: | HG_KWN:15910 | |||||||||
Type: | CpG-Island | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | MPROMDB | |||||||||
Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4 | |||||||||
Transcripts: | NM_003920, UC001SLG.1 | |||||||||
Position: |
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RGD ID: | 7224435 | |||||||||
Promoter ID: | EPDNEW_H17962 | |||||||||
Type: | initiation region | |||||||||
Name: | TIMELESS_1 | |||||||||
Description: | timeless circadian clock | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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Name | Type | Condition(s) | Position(s) | Clinical significance |
NM_003920.3(TIMELESS):c.3262C>T (p.Pro1088Ser) | single nucleotide variant | Malignant melanoma [RCV000070112] | Chr12:56418326 [GRCh38] Chr12:56812110 [GRCh37] Chr12:55098377 [NCBI36] Chr12:12q13.3 |
not provided |
NM_003920.3(TIMELESS):c.3190T>C (p.Leu1064=) | single nucleotide variant | Malignant melanoma [RCV000070113] | Chr12:56420607 [GRCh38] Chr12:56814391 [GRCh37] Chr12:55100658 [NCBI36] Chr12:12q13.3 |
not provided |
NM_003920.3(TIMELESS):c.829C>T (p.Arg277Ter) | single nucleotide variant | Malignant melanoma [RCV000070114] | Chr12:56430961 [GRCh38] Chr12:56824745 [GRCh37] Chr12:55111012 [NCBI36] Chr12:12q13.3 |
not provided |
NM_012064.3(MIP):c.373G>A (p.Val125Met) | single nucleotide variant | Malignant melanoma [RCV000062562] | Chr12:56453743 [GRCh38] Chr12:56847527 [GRCh37] Chr12:55133794 [NCBI36] Chr12:12q13.3 |
not provided |
NM_012064.3(MIP):c.559C>T (p.Arg187Cys) | single nucleotide variant | Malignant melanoma [RCV000070115] | Chr12:56453119 [GRCh38] Chr12:56846903 [GRCh37] Chr12:55133170 [NCBI36] Chr12:12q13.3 |
not provided |
NM_012064.3(MIP):c.558C>T (p.Ala186=) | single nucleotide variant | Malignant melanoma [RCV000070116] | Chr12:56453120 [GRCh38] Chr12:56846904 [GRCh37] Chr12:55133171 [NCBI36] Chr12:12q13.3 |
not provided |
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 | copy number gain | See cases [RCV000139555] | Chr12:121271..133196807 [GRCh38] Chr12:282465..133773393 [GRCh37] Chr12:100698..132283466 [NCBI36] Chr12:12p13.33-q24.33 |
pathogenic |
Single allele | copy number gain | See cases [RCV000258805] | Chr12:1..133851895 [GRCh37] | pathogenic|likely pathogenic |
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 | copy number gain | See cases [RCV000510482] | Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33 |
pathogenic |
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) | copy number gain | See cases [RCV000511643] | Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33 |
pathogenic |
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 | copy number gain | not provided [RCV000750253] | Chr12:621220..133779118 [GRCh37] Chr12:12p13.33-q24.33 |
pathogenic |
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 | copy number gain | not provided [RCV000750246] | Chr12:191619..133777645 [GRCh37] Chr12:12p13.33-q24.33 |
pathogenic |
Database | Acc Id | Source(s) |
AGR Gene | HGNC:11813 | AgrOrtholog |
COSMIC | TIMELESS | COSMIC |
Ensembl Genes | ENSG00000111602 | ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Protein | ENSP00000229201 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSP00000450607 | ENTREZGENE, UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENST00000229201 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENST00000553532 | ENTREZGENE, UniProtKB/Swiss-Prot | |
GTEx | ENSG00000111602 | GTEx |
HGNC ID | HGNC:11813 | ENTREZGENE |
Human Proteome Map | TIMELESS | Human Proteome Map |
InterPro | Timeless | UniProtKB/Swiss-Prot |
TIMELESS_C | UniProtKB/Swiss-Prot | |
KEGG Report | hsa:8914 | UniProtKB/Swiss-Prot |
NCBI Gene | 8914 | ENTREZGENE |
OMIM | 603887 | OMIM |
Pfam | TIMELESS | UniProtKB/Swiss-Prot |
TIMELESS_C | UniProtKB/Swiss-Prot | |
PharmGKB | PA36520 | PharmGKB |
UniGene | Hs.118631 | ENTREZGENE |
UniProt | Q9UNS1 | ENTREZGENE, UniProtKB/Swiss-Prot |
UniProt Secondary | B2ZAV0 | UniProtKB/Swiss-Prot |
O94802 | UniProtKB/Swiss-Prot | |
Q86VM1 | UniProtKB/Swiss-Prot | |
Q8IWH3 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2017-10-04 | TIMELESS | timeless circadian regulator | timeless circadian clock | Symbol and/or name change | 5135510 | APPROVED | |
2013-01-02 | TIMELESS | timeless circadian clock | timeless homolog (Drosophila) | Symbol and/or name change | 5135510 | APPROVED |
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More on TIMELESS | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: hg19 hg38 |
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HGNC Report |
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NCBI Genome Data Viewer |
CRRD Object Information | |
CRRD ID: | 731567 |
Created: | 2004-01-12 |
Species: | Homo sapiens |
Last Modified: | 2019-11-26 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.