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Gene: Fbn1 (fibrillin 1) Mus musculus
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Symbol: Fbn1
Name: fibrillin 1
Description: Predicted to have several functions, including heparin binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in negative regulation of osteoclast development; sequestering of BMP in extracellular matrix; and sequestering of TGFbeta in extracellular matrix. Localizes to the collagen-containing extracellular matrix and microfibril. Used to study Marfan syndrome; Weill-Marchesani syndrome; heart disease; pulmonary emphysema; and systemic scleroderma. Human ortholog(s) of this gene implicated in several diseases, including CREST syndrome; Weill-Marchesani syndrome; aortic disease (multiple); autosomal dominant isolated ectopia lentis 1; and bone disease (multiple). Is expressed in several structures, including cardiovascular system; connective tissue; genitourinary system; musculoskeletal system; and respiratory system. Orthologous to human FBN1 (fibrillin 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI536462; B430209H23; Fib-1; fibrillin-1; tight skin; Tsk
Orthologs:
Homo sapiens (human) : FBN1 (fibrillin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fbn1 (fibrillin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fbn1 (fibrillin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FBN1 (fibrillin 1)
Canis lupus familiaris (dog) : FBN1 (fibrillin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fbn1 (fibrillin 1)
Sus scrofa (pig) : FBN1 (fibrillin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382125,300,594 - 125,506,485 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372125,126,330 - 125,332,174 (-)NCBIGRCm37mm9NCBIm37
MGSCv362124,992,037 - 125,197,826 (-)NCBImm8
Celera2126,545,438 - 126,751,399 (-)NCBICelera
Cytogenetic Map2 F1NCBI
cM Map261.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations