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Gene: HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) Homo sapiens
Symbol: HMGCR
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
CRRD ID: 731579
Description: Exhibits nucleotide binding activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in cholesterol biosynthetic process. Localizes to endoplasmic reticulum and peroxisomal membrane. Implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; LDLCQ3
Mus musculus (house mouse) : Hmgcr (3-hydroxy-3-methylglutaryl-Coenzyme A reductase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Canis lupus familiaris (dog) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
Sus scrofa (pig) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Chlorocebus sabaeus (African green monkey) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Heterocephalus glaber (naked mole-rat) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl575,336,329 - 75,362,101 (+)EnsemblGRCh38hg38GRCh38
GRCh38575,336,334 - 75,362,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37574,632,159 - 74,657,926 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36574,668,855 - 74,693,681 (+)NCBINCBI36hg18NCBI36
Build 34574,668,854 - 74,693,681NCBI
Celera570,526,169 - 70,551,102 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef569,838,165 - 69,863,098 (+)NCBIHuRef
CHM1_1574,065,715 - 74,090,648 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HMGCR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731579
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.