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Gene: Hmgcr (3-hydroxy-3-methylglutaryl-Coenzyme A reductase) Mus musculus
Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Description: Exhibits hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in several processes, including negative regulation of amyloid-beta clearance; negative regulation of protein metabolic process; and visual learning. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum membrane; and peroxisomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Is expressed in several structures, including branchial arch; central nervous system; ganglia; limb; and vibrissa. Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid signaling pathway; cholesterol biosynthetic pathway; INTERACTS WITH 1,2,3-trilinolenoylglycerol; 1,2,3-trilinoleoylglycerol; 1,3-dichloropropan-2-ol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-hydroxy-3-methylglutaryl-CoA reductase; HMG-CoA reductase; HMG-CoAR; MGC103269; Red
Homo sapiens (human) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Canis lupus familiaris (dog) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
Sus scrofa (pig) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Chlorocebus sabaeus (African green monkey) : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)
Heterocephalus glaber (naked mole-rat) : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1396,648,967 - 96,670,936 (-)EnsemblGRCm38mm10GRCm38
GRCm381396,648,962 - 96,670,936 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371397,418,917 - 97,440,891 (-)NCBIGRCm37mm9NCBIm37
MGSCv361397,750,033 - 97,771,547 (-)NCBImm8
Celera13100,288,206 - 100,310,264 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hmgcr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731580
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.