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Gene: LPAR1 (lysophosphatidic acid receptor 1) Homo sapiens
Symbol: LPAR1
Name: lysophosphatidic acid receptor 1
CRRD ID: 731581
Description: Exhibits lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including activation of phospholipase C activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Localizes to cell surface; endosome; and plasma membrane. Colocalizes with endocytic vesicle.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: edg-2; EDG2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; Gpcr26; GPR26; LPA receptor 1; LPA-1; LPA1; lysophosphatidic acid receptor Edg-2; Mrec1.3; rec.1.3; ventricular zone gene 1; vzg-1; VZG1
Mus musculus (house mouse) : Lpar1 (lysophosphatidic acid receptor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lpar1 (lysophosphatidic acid receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lpar1 (lysophosphatidic acid receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LPAR1 (lysophosphatidic acid receptor 1)
Canis lupus familiaris (dog) : LPAR1 (lysophosphatidic acid receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lpar1 (lysophosphatidic acid receptor 1)
Sus scrofa (pig) : LPAR1 (lysophosphatidic acid receptor 1)
Chlorocebus sabaeus (African green monkey) : LPAR1 (lysophosphatidic acid receptor 1)
Heterocephalus glaber (naked mole-rat) : Lpar1 (lysophosphatidic acid receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl9110,873,263 - 111,038,458 (-)EnsemblGRCh38hg38GRCh38
GRCh389110,873,252 - 111,038,998 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379113,635,542 - 113,801,523 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,675,875 - 112,840,186 (-)NCBINCBI36hg18NCBI36
Build 349110,715,610 - 110,879,920NCBI
Celera984,135,330 - 84,299,600 (-)NCBI
Cytogenetic Map9q31.3NCBI
HuRef983,234,370 - 83,398,725 (-)NCBIHuRef
CHM1_19113,782,492 - 113,946,810 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on LPAR1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731581
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.