1-naphthyl isothiocyanate increases expression ISO RGD:620563 6480464 1-Naphthylisothiocyanate results in increased expression of LPAR1 mRNA CTD PMID:30723492 1-octadec-9-enoylglycero-3-phosphate increases response to substance EXP 6480464 LPAR1 protein results in increased susceptibility to lysophosphatidic acid CTD PMID:16809448 1-octadec-9-enoylglycero-3-phosphate multiple interactions EXP 6480464 LPAR1 protein affects the reaction [lysophosphatidic acid results in increased stability of and affects the localization of NFE2L2 protein] more ... CTD PMID:16224106 , PMID:25398768 17alpha-ethynylestradiol increases expression ISO RGD:620563 6480464 Ethinyl Estradiol results in increased expression of LPAR1 mRNA CTD PMID:12075121 , PMID:15901920 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of LPAR1 mRNA CTD PMID:14699072 17beta-estradiol increases expression ISO RGD:731582 6480464 Estradiol results in increased expression of LPAR1 mRNA CTD PMID:19484750 17beta-estradiol multiple interactions EXP 6480464 [Estradiol binds to ESR2 protein] which results in increased expression of LPAR1 mRNA CTD PMID:20404318 17beta-estradiol affects expression ISO RGD:731582 6480464 Estradiol affects the expression of LPAR1 mRNA CTD PMID:15598610 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of LPAR1 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731582 6480464 Tetrachlorodibenzodioxin affects the expression of LPAR1 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731582 6480464 Tetrachlorodibenzodioxin results in decreased expression of LPAR1 mRNA CTD PMID:18691609 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of LPAR1 mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:620563 6480464 3 more ... CTD PMID:23196670 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:731582 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of LPAR1 mRNA CTD PMID:26251327 4,4'-sulfonyldiphenol increases expression ISO RGD:731582 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of LPAR1 mRNA CTD PMID:30951980 4-hydroxynon-2-enal increases expression ISO RGD:731582 6480464 4-hydroxy-2-nonenal results in increased expression of LPAR1 mRNA CTD PMID:19191707 4-hydroxyphenyl retinamide increases expression ISO RGD:731582 6480464 Fenretinide results in increased expression of LPAR1 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 [Decitabine co-treated with Vorinostat] affects the expression of LPAR1 mRNA CTD PMID:17330099 6-propyl-2-thiouracil decreases expression ISO RGD:620563 6480464 Propylthiouracil results in decreased expression of LPAR1 mRNA CTD PMID:24780913 , PMID:25825206 acrolein decreases expression ISO RGD:731582 6480464 Acrolein results in decreased expression of LPAR1 mRNA CTD PMID:18515264 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of LPAR1 mRNA CTD PMID:21934132 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of LPAR1 mRNA CTD PMID:23724009 ammonium chloride affects expression ISO RGD:620563 6480464 Ammonium Chloride affects the expression of LPAR1 mRNA CTD PMID:16483693 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of LPAR1 mRNA CTD PMID:22378314 belinostat decreases expression EXP 6480464 belinostat results in decreased expression of LPAR1 mRNA CTD PMID:27188386 benzo[a]pyrene increases mutagenesis EXP 6480464 Benzo(a)pyrene results in increased mutagenesis of LPAR1 gene CTD PMID:25435355 benzo[a]pyrene increases expression ISO RGD:731582 6480464 Benzo(a)pyrene results in increased expression of LPAR1 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I affects expression EXP 6480464 7 more ... CTD PMID:20382639 beta-naphthoflavone multiple interactions ISO RGD:620563 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPAR1 mRNA CTD PMID:18164116 bisphenol A increases expression ISO RGD:620563 6480464 bisphenol A results in increased expression of LPAR1 mRNA CTD PMID:12075121 more ... bisphenol A increases methylation ISO RGD:620563 6480464 bisphenol A results in increased methylation of LPAR1 gene CTD PMID:28505145 bisphenol A increases expression ISO RGD:731582 6480464 bisphenol A results in increased expression of LPAR1 mRNA CTD PMID:25594700 , PMID:30951980 bisphenol A decreases expression ISO RGD:620563 6480464 bisphenol A results in decreased expression of LPAR1 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:731582 6480464 bisphenol F results in increased expression of LPAR1 mRNA CTD PMID:30951980 butan-1-ol multiple interactions EXP 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of LPAR1 mRNA CTD PMID:29432896 butanal decreases expression EXP 6480464 butyraldehyde results in decreased expression of LPAR1 mRNA CTD PMID:26079696 C60 fullerene decreases expression ISO RGD:620563 6480464 fullerene C60 results in decreased expression of LPAR1 mRNA CTD PMID:19167457 calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of LPAR1 mRNA CTD PMID:26485663 chloroprene increases expression ISO RGD:731582 6480464 Chloroprene results in increased expression of LPAR1 mRNA CTD PMID:23125180 chloroprene increases expression ISO RGD:620563 6480464 Chloroprene results in increased expression of LPAR1 mRNA CTD PMID:23125180 chlorpyrifos decreases expression ISO RGD:620563 6480464 Chlorpyrifos results in decreased expression of LPAR1 mRNA CTD PMID:18668222 choline multiple interactions ISO RGD:731582 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LPAR1 gene, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LPAR1 mRNA CTD PMID:20938992 chromium(6+) affects expression ISO RGD:731582 6480464 chromium hexavalent ion affects the expression of LPAR1 mRNA CTD PMID:28472532 cisplatin decreases expression ISO RGD:731582 6480464 Cisplatin results in decreased expression of LPAR1 mRNA CTD PMID:21151649 cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of LPAR1 mRNA CTD PMID:15009677 corticosterone increases expression ISO RGD:620563 6480464 Corticosterone results in increased expression of LPAR1 mRNA CTD PMID:15755911 curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of LPAR1 mRNA CTD PMID:17999991 dibutyl phthalate decreases expression ISO RGD:620563 6480464 Dibutyl Phthalate results in decreased expression of LPAR1 mRNA CTD PMID:21266533 , PMID:24893172 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects response to substance EXP 6480464 LPAR1 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 elemental selenium increases expression EXP 6480464 Selenium results in increased expression of LPAR1 mRNA CTD PMID:19244175 endosulfan decreases expression ISO RGD:620563 6480464 Endosulfan results in decreased expression of LPAR1 mRNA CTD PMID:29391264 ethanol multiple interactions ISO RGD:731582 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LPAR1 mRNA CTD PMID:30517762 ethanol increases expression ISO RGD:731582 6480464 Ethanol results in increased expression of LPAR1 mRNA CTD PMID:30319688 ethanol affects splicing ISO RGD:731582 6480464 Ethanol affects the splicing of LPAR1 mRNA CTD PMID:30319688 ethyl methanesulfonate decreases expression EXP 6480464 Ethyl Methanesulfonate results in decreased expression of LPAR1 mRNA CTD PMID:23649840 flavonoids increases expression ISO RGD:620563 6480464 Flavonoids results in increased expression of LPAR1 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:731582 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LPAR1 gene, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LPAR1 mRNA CTD PMID:20938992 folic acid increases expression ISO RGD:731582 6480464 Folic Acid results in increased expression of LPAR1 mRNA CTD PMID:25006883 fonofos increases methylation EXP 6480464 Fonofos results in increased methylation of LPAR1 promoter CTD PMID:22847954 furan increases expression ISO RGD:620563 6480464 furan results in increased expression of LPAR1 mRNA CTD PMID:27387713 genistein increases expression ISO RGD:620563 6480464 Genistein results in increased expression of LPAR1 mRNA CTD PMID:12075121 hydrazine decreases expression ISO RGD:731582 6480464 hydrazine results in decreased expression of LPAR1 mRNA CTD PMID:15282401 iron atom decreases expression ISO RGD:620563 6480464 Iron deficiency results in decreased expression of LPAR1 mRNA CTD PMID:19821111 iron(0) decreases expression ISO RGD:620563 6480464 Iron deficiency results in decreased expression of LPAR1 mRNA CTD PMID:19821111 L-methionine multiple interactions ISO RGD:731582 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LPAR1 gene, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LPAR1 mRNA CTD PMID:20938992 lead(0) decreases expression EXP 6480464 Lead results in decreased expression of LPAR1 mRNA CTD PMID:19921347 lead(0) affects expression EXP 6480464 Lead affects the expression of LPAR1 mRNA CTD PMID:28903495 lead(2+) decreases expression EXP 6480464 Lead results in decreased expression of LPAR1 mRNA CTD PMID:19921347 lead(2+) affects expression EXP 6480464 Lead affects the expression of LPAR1 mRNA CTD PMID:28903495 lipopolysaccharide multiple interactions ISO RGD:731582 6480464 3 more ... CTD PMID:21821728 , PMID:25843059 lipopolysaccharide affects response to substance ISO RGD:731582 6480464 LPAR1 affects the susceptibility to Lipopolysaccharides CTD PMID:21821728 lipopolysaccharide increases expression ISO RGD:731582 6480464 Lipopolysaccharides results in increased expression of LPAR1 mRNA, Lipopolysaccharides results in increased expression of LPAR1 protein CTD PMID:21821728 , PMID:25843059 manganese(II) chloride decreases expression ISO RGD:620563 6480464 manganese chloride results in decreased expression of LPAR1 mRNA CTD PMID:28801915 methotrexate affects response to substance EXP 6480464 LPAR1 protein affects the susceptibility to Methotrexate CTD PMID:16217747 methoxychlor increases methylation ISO RGD:620563 6480464 Methoxychlor results in increased methylation of LPAR1 gene CTD PMID:23303685 methyl beta-cyclodextrin multiple interactions ISO RGD:731582 6480464 methyl-beta-cyclodextrin inhibits the reaction [Lipopolysaccharides promotes the reaction [LPAR1 protein binds to CD14 protein]] CTD PMID:21821728 N-methyl-4-phenylpyridinium decreases expression ISO RGD:620563 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of LPAR1 mRNA CTD PMID:28801915 N-nitrosodiethylamine multiple interactions ISO RGD:620563 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPAR1 mRNA CTD PMID:18164116 oxaliplatin multiple interactions ISO RGD:620563 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of LPAR1 mRNA CTD PMID:25729387 oxaliplatin increases expression ISO RGD:620563 6480464 oxaliplatin results in increased expression of LPAR1 mRNA CTD PMID:25729387 parathion increases methylation EXP 6480464 Parathion results in increased methylation of LPAR1 promoter CTD PMID:22847954 perfluorooctane-1-sulfonic acid affects expression ISO RGD:620563 6480464 perfluorooctane sulfonic acid affects the expression of LPAR1 mRNA CTD PMID:20136073 phenylmercury acetate decreases expression EXP 6480464 Phenylmercuric Acetate results in decreased expression of LPAR1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA CTD PMID:27188386 progesterone increases expression ISO RGD:620563 6480464 Progesterone results in increased expression of LPAR1 mRNA CTD PMID:20726854 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenium atom increases expression EXP 6480464 Selenium results in increased expression of LPAR1 mRNA CTD PMID:19244175 silver atom decreases expression ISO RGD:731582 6480464 Silver results in decreased expression of LPAR1 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:731582 6480464 Silver results in decreased expression of LPAR1 mRNA CTD PMID:27131904 sodium fluoride decreases expression ISO RGD:731582 6480464 Sodium Fluoride results in decreased expression of LPAR1 mRNA CTD PMID:27862939 succimer multiple interactions ISO RGD:731582 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of LPAR1 mRNA CTD PMID:21641980 terbufos increases methylation EXP 6480464 terbufos results in increased methylation of LPAR1 promoter CTD PMID:22847954 tetrachloromethane affects expression ISO RGD:731582 6480464 Carbon Tetrachloride affects the expression of LPAR1 mRNA CTD PMID:17484886 tetrachloromethane multiple interactions ISO RGD:731582 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LPAR1 mRNA CTD PMID:30517762 tipifarnib increases expression ISO RGD:620563 6480464 tipifarnib results in increased expression of LPAR1 mRNA CTD PMID:16403772 titanium dioxide increases expression ISO RGD:731582 6480464 titanium dioxide results in increased expression of LPAR1 mRNA CTD PMID:23557971 , PMID:27760801 titanium dioxide affects expression ISO RGD:731582 6480464 titanium dioxide affects the expression of LPAR1 mRNA CTD PMID:17656681 topotecan multiple interactions ISO RGD:620563 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of LPAR1 mRNA CTD PMID:25729387 topotecan increases expression ISO RGD:620563 6480464 Topotecan results in increased expression of LPAR1 mRNA CTD PMID:25729387 trichostatin A decreases expression EXP 6480464 trichostatin A results in decreased expression of LPAR1 mRNA CTD PMID:26272509 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA CTD PMID:27188386 triclosan increases expression EXP 6480464 Triclosan results in increased expression of LPAR1 mRNA CTD PMID:30510588 undecane increases expression ISO RGD:620563 6480464 undecane results in increased expression of LPAR1 protein CTD PMID:17337753 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of LPAR1 mRNA CTD PMID:19101580 valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA CTD PMID:27188386 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of LPAR1 mRNA CTD PMID:23179753 more ... valproic acid increases expression ISO RGD:731582 6480464 Valproic Acid results in increased expression of LPAR1 mRNA CTD PMID:19136453 , PMID:24896083 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of LPAR1 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:620563 6480464 Valproic Acid results in increased expression of LPAR1 mRNA CTD PMID:23665938 vincaleukoblastine affects response to substance EXP 6480464 LPAR1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 vitamin E increases expression EXP 6480464 Vitamin E results in increased expression of LPAR1 mRNA CTD PMID:19244175 vorinostat multiple interactions EXP 6480464 [decitabine co-treated with vorinostat] affects the expression of LPAR1 mRNA CTD PMID:17330099 zaragozic acid A decreases expression ISO RGD:620563 6480464 squalestatin 1 results in decreased expression of LPAR1 mRNA CTD PMID:27225895 zaragozic acid A increases expression ISO RGD:731582 6480464 squalestatin 1 results in increased expression of LPAR1 mRNA CTD PMID:27225895
Biological Process activation of MAPK activity IEA UniProtKB:P61793 , ensembl:ENSMUSP000001031972290271 Ensembl GO_REF:0000107 activation of phospholipase C activity IDA 2290271 (PMID:19306925) UniProtKB PMID:19306925 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS UniProtKB:P61793 2290271 UniProtKB GO_REF:0000024 bleb assembly IEA UniProtKB:P61793 , ensembl:ENSMUSP000001031972290271 Ensembl GO_REF:0000107 cell chemotaxis IMP 2290271 (PMID:19733258) UniProtKB PMID:19733258 cellular response to 1-oleoyl-sn-glycerol 3-phosphate IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 cellular response to oxygen levels IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 cerebellum development IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 corpus callosum development IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 G protein-coupled receptor signaling pathway TAS 2290271 Reactome Reactome:R-HSA-388396 G protein-coupled receptor signaling pathway IEA UniProtKB-KW:KW-0297 2290271 UniProtKB GO_REF:0000038 myelination IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 negative regulation of cAMP-mediated signaling IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 negative regulation of neuron projection development ISS UniProtKB:P61793 2290271 UniProtKB GO_REF:0000024 oligodendrocyte development IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 optic nerve development IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 positive regulation of apoptotic process IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 positive regulation of cytosolic calcium ion concentration TAS 2290271 (PMID:9804623) PINC PMID:9804623 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IMP 2290271 (PMID:19733258) UniProtKB PMID:19733258 positive regulation of dendritic spine development IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP 2290271 (PMID:12761501) UniProtKB PMID:12761501 positive regulation of MAPK cascade ISS UniProtKB:P61793 2290271 UniProtKB GO_REF:0000024 positive regulation of Rho protein signal transduction ISS UniProtKB:P61793 2290271 UniProtKB GO_REF:0000024 positive regulation of smooth muscle cell chemotaxis IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 positive regulation of stress fiber assembly ISS UniProtKB:P61793 2290271 UniProtKB GO_REF:0000024 regulation of cell shape ISS UniProtKB:P61793 2290271 UniProtKB GO_REF:0000024 Cellular Component cell IEA GO:0051482 2290271 GOC GO_REF:0000108 cell IEA GO:0007204 2290271 GOC GO_REF:0000108 cell surface IDA 2290271 (PMID:19306925) UniProtKB PMID:19306925 dendritic shaft IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 dendritic spine IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 endocytic vesicle colocalizes_with IDA 2290271 (PMID:19306925) UniProtKB PMID:19306925 endosome IDA 2290271 (PMID:19306925) UniProtKB PMID:19306925 integral component of membrane IEA UniProtKB-KW:KW-0812 2290271 UniProtKB GO_REF:0000038 integral component of plasma membrane ISS UniProtKB:P61793 2290271 UniProtKB GO_REF:0000024 neuronal cell body IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 plasma membrane IDA 2290271 (PMID:19306925) UniProtKB PMID:19306925 plasma membrane TAS 2290271 Reactome Reactome:R-HSA-379048 more ... Molecular Function G protein-coupled receptor activity TAS 2290271 (PMID:8922387) PINC PMID:8922387 G-protein alpha-subunit binding IEA UniProtKB:P61794 , ensembl:ENSRNOP000000436522290271 Ensembl GO_REF:0000107 lysophosphatidic acid binding IDA 2290271 (PMID:9070858) UniProtKB PMID:9070858 lysophosphatidic acid receptor activity IDA 2290271 (PMID:19306925) UniProtKB PMID:19306925 lysophosphatidic acid receptor activity IEA InterPro:IPR002277 , InterPro:IPR004065 2290271 InterPro GO_REF:0000002 lysophosphatidic acid receptor activity IMP 2290271 (PMID:9070858) UniProtKB PMID:9070858 PDZ domain binding IEA UniProtKB:P61793 , ensembl:ENSMUSP000001031972290271 Ensembl GO_REF:0000107 protein binding IPI UniProtKB:P11233 2290271 (PMID:19306925) UniProtKB PMID:19306925 protein binding IPI UniProtKB:P25098 2290271 (PMID:19306925) UniProtKB PMID:19306925
Gene-Chemical Interaction Annotations
