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Gene: PLS3 (plastin 3) Homo sapiens
Symbol: PLS3
Name: plastin 3
Description: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMND18; DKFZp686G1497; plastin 3 (t-isoform); plastin-3; T fimbrin; T plastin; T-plastin
Mus musculus (house mouse) : Pls3 (plastin 3 (T-isoform))  MGI  Alliance
Rattus norvegicus (Norway rat) : Pls3 (plastin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pls3 (plastin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PLS3 (plastin 3)
Canis lupus familiaris (dog) : PLS3 (plastin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pls3 (plastin 3)
Sus scrofa (pig) : PLS3 (plastin 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X115,560,850 - 115,650,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X114,795,177 - 114,885,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X114,701,765 - 114,791,246 (+)NCBINCBI36hg18NCBI36
Build 34X114,618,488 - 114,707,970NCBI
CeleraX115,230,242 - 115,320,243 (+)NCBI
Cytogenetic MapXq23NCBI
HuRefX104,379,340 - 104,468,198 (+)NCBIHuRef
CHM1_1X114,706,001 - 114,796,082 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PLS3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731591
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.