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Gene: ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) Homo sapiens
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Symbol: ATIC
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Description: Exhibits protein homodimerization activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Localizes to the cytosol and plasma membrane. Implicated in purine-pyrimidine metabolic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/imp; 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICARFT; AICARFT/IMPCHASE; bifunctional purine biosynthesis protein PURH; epididymis secretory sperm binding protein Li 70p; FLJ93545; HEL-S-70p; IMPCHASE; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PURH
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382215,311,974 - 215,359,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372216,176,679 - 216,214,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,885,081 - 215,922,724 (+)NCBINCBI36hg18NCBI36
Build 342216,002,341 - 216,039,983NCBI
Celera2209,946,316 - 209,984,125 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2208,033,447 - 208,071,522 (+)NCBIHuRef
CHM1_12216,182,580 - 216,220,395 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ATIC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731594
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.