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Gene: HAND2 (heart and neural crest derivatives expressed 2) Homo sapiens
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Symbol: HAND2
Name: heart and neural crest derivatives expressed 2
Description: Exhibits AT DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and E-box binding activity. Predicted to contribute to transcription regulatory region DNA binding activity. Involved in several processes, including adult heart development; positive regulation of MAPK cascade; and regulation of gene expression. Localizes to the nuclear chromatin and protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic helix-loop-helix transcription factor HAND2; bHLHa26; class A basic helix-loop-helix protein 26; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHand; DHAND2; FLJ16260; heart- and neural crest derivatives-expressed protein 2; Hed; MGC125303; MGC125304; Thing2
Orthologs:
Mus musculus (house mouse) : Hand2 (heart and neural crest derivatives expressed 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hand2 (heart and neural crest derivatives expressed 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hand2 (heart and neural crest derivatives expressed 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HAND2 (heart and neural crest derivatives expressed 2)
Canis lupus familiaris (dog) : HAND2 (heart and neural crest derivatives expressed 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hand2 (heart and neural crest derivatives expressed 2)
Sus scrofa (pig) : HAND2 (heart and neural crest derivatives expressed 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384173,526,091 - 173,530,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374174,447,652 - 174,451,378 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,684,227 - 174,687,953 (-)NCBINCBI36hg18NCBI36
Build 344174,820,849 - 174,825,309NCBI
Celera4171,772,735 - 171,776,461 (-)NCBI
Cytogenetic Map4q34.1NCBI
HuRef4170,194,314 - 170,197,710 (-)NCBIHuRef
CHM1_14174,424,466 - 174,428,102 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HAND2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731603
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.