Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Vcp (valosin containing protein) Mus musculus
Symbol: Vcp
Name: valosin containing protein
Description: Exhibits several functions, including K48-linked polyubiquitin modification-dependent protein binding activity; adenyl ribonucleotide binding activity; and ubiquitin-specific protease binding activity. Involved in several processes, including aggresome assembly; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Localizes to several cellular components, including ATPase complex; VCP-NSFL1C complex; and endoplasmic reticulum membrane. Used to study inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Is expressed in several structures, including cerebral cortex; early embryo; genitourinary system; gut; and liver. Orthologous to human VCP (valosin containing protein); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 15S Mg(2+)-ATPase p97 subunit; 3110001E05; AAA ATPase p97; CDC48; homolog of yeast cdc48; Inv protein; p97; p97/VCP; TER ATPase; transitional endoplasmic reticulum ATPase; valosin-containing protein
Homo sapiens (human) : VCP (valosin containing protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Vcp (valosin-containing protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vcp (valosin containing protein)
Pan paniscus (bonobo/pygmy chimpanzee) : VCP (valosin containing protein)
Canis lupus familiaris (dog) : VCP (valosin containing protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vcp (valosin containing protein)
Sus scrofa (pig) : VCP (valosin containing protein)
Chlorocebus sabaeus (African green monkey) : VCP (valosin containing protein)
Heterocephalus glaber (naked mole-rat) : Vcp (valosin containing protein)
more info ...
Related Pseudogenes: Vcp-rs  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl442,979,963 - 43,000,507 (-)EnsemblGRCm38mm10GRCm38
GRCm38442,979,964 - 43,000,507 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37442,992,836 - 43,013,379 (-)NCBIGRCm37mm9NCBIm37
MGSCv36443,001,064 - 43,021,534 (-)NCBImm8
Celera443,010,123 - 43,030,659 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Vcp
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731622
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.