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Gene: Vcp (valosin containing protein) Mus musculus
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Symbol: Vcp
Name: valosin containing protein
Description: Exhibits several functions, including K48-linked polyubiquitin modification-dependent protein binding activity; adenyl ribonucleotide binding activity; and ubiquitin-specific protease binding activity. Involved in several processes, including aggresome assembly; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Localizes to several cellular components, including ATPase complex; VCP-NSFL1C complex; and endoplasmic reticulum membrane. Used to study inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Is expressed in several structures, including cerebral cortex; early embryo; genitourinary system; gut; and liver. Orthologous to human VCP (valosin containing protein); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 15S Mg(2+)-ATPase p97 subunit; 3110001E05; AAA ATPase p97; CDC48; homolog of yeast cdc48; Inv protein; p97; p97/VCP; TER ATPase; transitional endoplasmic reticulum ATPase; valosin-containing protein
Orthologs:
Homo sapiens (human) : VCP (valosin containing protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Vcp (valosin-containing protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vcp (valosin containing protein)
Pan paniscus (bonobo/pygmy chimpanzee) : VCP (valosin containing protein)
Canis lupus familiaris (dog) : VCP (valosin containing protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vcp (valosin containing protein)
Sus scrofa (pig) : VCP (valosin containing protein)
Chlorocebus sabaeus (African green monkey) : VCP (valosin containing protein)
Heterocephalus glaber (naked mole-rat) : Vcp (valosin containing protein)
more info ...
Related Pseudogenes: Vcp-rs  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl442,979,963 - 43,000,507 (-)EnsemblGRCm38mm10GRCm38
GRCm38442,979,964 - 43,000,507 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37442,992,836 - 43,013,379 (-)NCBIGRCm37mm9NCBIm37
MGSCv36443,001,064 - 43,021,534 (-)NCBImm8
Celera443,010,123 - 43,030,659 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Vcp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731622
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.