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Gene: ATP2B3 (ATPase plasma membrane Ca2+ transporting 3) Homo sapiens
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Symbol: ATP2B3
Name: ATPase plasma membrane Ca2+ transporting 3
Description: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATPase, Ca++ transporting, plasma membrane 3; cerebellar ataxia 2 (X-linked); CFAP39; cilia and flagella associated protein 39; CLA2; OPCA; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 3; PMCA3; PMCA3a; SCAX1
Orthologs:
Mus musculus (house mouse) : Atp2b3 (ATPase, Ca++ transporting, plasma membrane 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atp2b3 (ATPase plasma membrane Ca2+ transporting 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp2b3 (ATPase plasma membrane Ca2+ transporting 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP2B3 (ATPase plasma membrane Ca2+ transporting 3)
Canis lupus familiaris (dog) : ATP2B3 (ATPase plasma membrane Ca2+ transporting 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp2b3 (ATPase plasma membrane Ca2+ transporting 3)
Sus scrofa (pig) : ATP2B3 (ATPase plasma membrane Ca2+ transporting 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,517,677 - 153,582,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X152,783,905 - 152,848,387 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,454,774 - 152,501,581 (+)NCBINCBI36hg18NCBI36
Build 34X152,322,426 - 152,369,234NCBI
CeleraX153,035,263 - 153,082,068 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,460,036 - 141,506,946 (+)NCBIHuRef
CHM1_1X152,676,076 - 152,722,878 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ATP2B3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731628
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.