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Gene: SOX10 (SRY-box transcription factor 10) Homo sapiens
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Symbol: SOX10
Name: SRY-box transcription factor 10
Description: Exhibits identical protein binding activity. Predicted to be involved in several processes, including nervous system development; neural crest cell migration; and positive regulation of transcription by RNA polymerase II. Localizes to the nucleoplasm. Implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DOM; dominant megacolon, mouse, human homolog of; MGC15649; PCWH; SRY (sex determining region Y)-box 10; SRY box 10; SRY-box 10; sry-box containing gene 10; SRY-related HMG-box gene 10; transcription factor SOX-10; WS2E; WS4; WS4C
Orthologs:
Mus musculus (house mouse) : Sox10 (SRY (sex determining region Y)-box 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sox10 (SRY-box transcription factor 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox10 (SRY-box transcription factor 10)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX10 (SRY-box transcription factor 10)
Canis lupus familiaris (dog) : SOX10 (SRY-box transcription factor 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sox10 (SRY-box transcription factor 10)
Sus scrofa (pig) : SOX10 (SRY-box transcription factor 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,972,312 - 37,984,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372238,368,319 - 38,380,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,698,265 - 36,710,485 (-)NCBINCBI36hg18NCBI36
Build 342236,692,819 - 36,705,039NCBI
Celera2222,170,048 - 22,182,268 (-)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2221,334,376 - 21,346,534 (-)NCBIHuRef
CHM1_12238,327,060 - 38,339,280 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SOX10
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731681
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.