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Gene: CD81 (CD81 molecule) Homo sapiens
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Symbol: CD81
Name: CD81 molecule
Description: Exhibits cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of immune response; and positive regulation of lymphocyte activation. Localizes to several cellular components, including the extracellular exosome; immunological synapse; and tetraspanin-enriched microdomain. Implicated in common variable immunodeficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 26 kDa cell surface protein TAPA-1; cd 81 antigen; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; TAPA1; target of antiproliferative antibody 1; target of the antiproliferative antibody 1; tetraspanin-28; tspan-28; TSPAN28
Orthologs:
Mus musculus (house mouse) : Cd81 (CD81 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd81 (Cd81 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd81 (CD81 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD81 (CD81 molecule)
Canis lupus familiaris (dog) : CD81 (CD81 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd81 (CD81 molecule)
Sus scrofa (pig) : CD81 (CD81 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,376,177 - 2,397,419 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,397,391 - 2,418,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,355,123 - 2,375,225 (+)NCBINCBI36hg18NCBI36
Build 34112,355,315 - 2,375,202NCBI
Celera112,433,431 - 2,453,456 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef112,188,870 - 2,209,001 (+)NCBIHuRef
CHM1_1112,396,358 - 2,417,522 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CD81
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731700
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.