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Gene: RB1 (RB transcriptional corepressor 1) Homo sapiens
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Symbol: RB1
Name: RB transcriptional corepressor 1
Description: Exhibits several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in several processes, including regulation of kinase activity; regulation of sister chromatid segregation; and sister chromatid segregation. Localizes to the PML body and Rb-E2F complex. Colocalizes with the cyclin/CDK positive transcription elongation factor complex. Implicated in several diseases, including malignant glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Biomarker of germ cell cancer (multiple); glioblastoma proneural subtype; in situ carcinoma (multiple); obesity; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p105-Rb; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; RB; retinoblastoma 1; retinoblastoma suspectibility protein; retinoblastoma-associated protein
Orthologs:
Mus musculus (house mouse) : Rb1 (RB transcriptional corepressor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rb1 (RB transcriptional corepressor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rb1 (RB transcriptional corepressor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RB1 (RB transcriptional corepressor 1)
Canis lupus familiaris (dog) : RB1 (RB transcriptional corepressor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rb1 (RB transcriptional corepressor 1)
Sus scrofa (pig) : RB1 (RB transcriptional corepressor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,303,747 - 48,481,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371348,877,883 - 49,056,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,775,884 - 47,954,027 (+)NCBINCBI36hg18NCBI36
Build 341347,775,911 - 47,954,023NCBI
Celera1329,932,627 - 30,110,747 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,670,144 - 29,848,118 (+)NCBIHuRef
CHM1_11348,845,597 - 49,023,603 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated