Gene: CYB5R3 (cytochrome b5 reductase 3) Homo sapiens
Analyze
Symbol:
CYB5R3
Name:
cytochrome b5 reductase 3
Description:
Exhibits FAD binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; neutrophil degranulation; and xenobiotic metabolic process. Localizes to the endoplasmic reticulum and lipid droplet. Implicated in breast cancer and methemoglobinemia. Biomarker of estrogen-receptor negative breast cancer.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
B5R; DIA1; diaphorase 1; diaphorase-1; mutant NADH-cytochrome b5 reductase; NADH-cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Cyb5r3 (cytochrome b5 reductase 3) HGNC
EggNOG, Ensembl, HGNC, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Cyb5r3 (cytochrome b5 reductase 3) HGNC
Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):
LOC102012303 (NADH-cytochrome b5 reductase 3) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
LOC100982559 (NADH-cytochrome b5 reductase 3) NCBI
Ortholog
Canis lupus familiaris (dog):
CYB5R3 (cytochrome b5 reductase 3) HGNC
Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
LOC101962805 (NADH-cytochrome b5 reductase 3) NCBI
Ortholog
Sus scrofa (pig):
LOC100524254 (NADH-cytochrome b5 reductase 3-like) HGNC
Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Treefam
Other homologs 2
Sus scrofa (pig):
LOC100622980 (cytochrome b5 reductase 4) HGNC
Panther
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cyb5r3 (cytochrome b5 reductase 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Cyb5r3 (cytochrome b5 reductase 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
cyb5r3 (cytochrome b5 reductase 3)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
AIM33
Alliance
DIOPT (InParanoid, OMA, TreeFam)
Drosophila melanogaster (fruit fly):
CG5946
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Saccharomyces cerevisiae (baker's yeast):
CBR1
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, OrthoInspector, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
T05H4.4
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
hpo-19
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Saccharomyces cerevisiae (baker's yeast):
PGA3
Alliance
DIOPT (InParanoid, OMA, OrthoFinder, OrthoInspector, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
MCR1
Alliance
DIOPT (OMA, PhylomeDB, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 22 42,617,840 - 42,649,392 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 22 43,013,846 - 43,045,405 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 22 41,344,763 - 41,375,349 (-) NCBI NCBI36 hg18 NCBI36 Build 34 22 41,339,318 - 41,367,516 NCBI Celera 22 26,924,326 - 26,955,882 (-) NCBI Cytogenetic Map 22 q13.2 NCBI HuRef 22 25,974,473 - 26,005,949 (-) NCBI HuRef CHM1_1 22 42,972,995 - 43,004,519 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
NADH Cytochrome B5 Reductase Deficiency IAGP RGD:13528166 8554872 ClinVar Annotator: match by term: Hereditary methemoglobinemia ClinVar PMID:11159544 more ... NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555524 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:18318771 , PMID:7718898 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555529 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:10874300 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555522 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:18318771 , PMID:7718898 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555527 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:15921385 , PMID:9266404 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555520 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:7668255 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555530 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:10874300 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555521 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:7718898 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555532 8554872 ClinVar Annotator: match by term: Methemoglobinemia, type I ClinVar PMID:12393396 more ... NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555519 8554872 ClinVar Annotator: match by term: Methemoglobinemia, type I ClinVar PMID:1400360 , PMID:18318771 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555534 8554872 ClinVar Annotator: match by term: Methemoglobinemia, type I ClinVar PMID:15953014 , PMID:18318771 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555518 8554872 ClinVar Annotator: match by term: Methemoglobinemia, type I ClinVar PMID:1707593 more ... NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555525 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:18318771 , PMID:8119939 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555517 8554872 ClinVar Annotator: match by term: Methemoglobinemia, type I ClinVar PMID:1707593 , PMID:18318771 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555531 8554872 ClinVar Annotator: match by term: Methemoglobinemia, type I ClinVar PMID:10807796 , PMID:18318771 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555516 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:18318771 more ... NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555528 8554872 ClinVar Annotator: match by term: Methemoglobinemia, type I ClinVar PMID:18318771 , PMID:9695975 NADH Cytochrome B5 Reductase Deficiency IAGP RGD:8555523 8554872 ClinVar Annotator: match by term: METHEMOGLOBINEMIA, TYPE II ClinVar PMID:15921385 more ...
Imported Annotations - CTD
Cyanosis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16469290 methemoglobinemia EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16469290 Imported Annotations - OMIM
NADH Cytochrome B5 Reductase Deficiency IAGP 7240710 OMIM
1,2-dichloroethane decreases expression ISO RGD:1557763 6480464 ethylene dichloride results in decreased expression of CYB5R3 mRNA CTD PMID:28189721 1-naphthyl isothiocyanate decreases expression ISO RGD:2502 6480464 1-Naphthylisothiocyanate results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 17alpha-ethynylestradiol decreases expression ISO RGD:2502 6480464 Ethinyl Estradiol results in decreased expression of CYB5R3 mRNA CTD PMID:17108234 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1557763 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:2502 6480464 Tetrachlorodibenzodioxin results in increased expression of CYB5R3 protein CTD PMID:16548065 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1557763 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28213091 , PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:2502 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYB5R3 mRNA CTD PMID:21215274 , PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CYB5R3 mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1557763 6480464 Tetrachlorodibenzodioxin affects the expression of CYB5R3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1557763 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYB5R3 mRNA CTD PMID:21354282 , PMID:28213091 2,4-dinitrotoluene affects expression ISO RGD:2502 6480464 2, 4-dinitrotoluene affects the expression of CYB5R3 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:2502 6480464 2, 6-dinitrotoluene affects the expression of CYB5R3 mRNA CTD PMID:21346803 2-nitrofluorene decreases expression ISO RGD:2502 6480464 2-nitrofluorene results in decreased expression of CYB5R3 mRNA CTD PMID:14600272 3-chloropropane-1,2-diol increases expression ISO RGD:2502 6480464 alpha-Chlorohydrin results in increased expression of CYB5R3 mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CYB5R3 mRNA CTD PMID:28628672 3H-1,2-dithiole-3-thione increases expression ISO RGD:2502 6480464 1, 2-dithiol-3-thione results in increased expression of CYB5R3 mRNA CTD PMID:19162173 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression ISO RGD:2502 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CYB5R3 mRNA CTD PMID:14600272 7,12-dimethyltetraphene affects expression ISO RGD:1557763 6480464 9 more ... CTD PMID:21785161 acrylamide increases expression ISO RGD:2502 6480464 Acrylamide results in increased expression of CYB5R3 mRNA CTD PMID:28959563 acrylamide increases expression ISO RGD:1557763 6480464 Acrylamide results in increased expression of CYB5R3 mRNA CTD PMID:30807115 aflatoxin B1 decreases expression ISO RGD:1557763 6480464 Aflatoxin B1 results in decreased expression of CYB5R3 mRNA CTD PMID:19770486 alpha-hexachlorocyclohexane increases expression ISO RGD:2502 6480464 alpha-hexachlorocyclohexane results in increased expression of CYB5R3 mRNA CTD PMID:17785943 ammonium chloride affects expression ISO RGD:2502 6480464 Ammonium Chloride affects the expression of CYB5R3 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:1557763 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CYB5R3 mRNA CTD PMID:23650126 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CYB5R3 mRNA CTD PMID:15725085 benzamidoxime multiple interactions EXP 6480464 [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime, [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 benzo[a]pyrene decreases expression ISO RGD:1557763 6480464 Benzo(a)pyrene results in decreased expression of CYB5R3 mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of CYB5R3 intron CTD PMID:30157460 benzo[a]pyrene affects expression ISO RGD:1557763 6480464 Benzo(a)pyrene affects the expression of CYB5R3 mRNA CTD PMID:22342234 benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:20018196 Benzo[k]fluoranthene decreases expression ISO RGD:1557763 6480464 benzo(k)fluoranthene results in decreased expression of CYB5R3 mRNA CTD PMID:26377693 bezafibrate affects expression ISO RGD:2502 6480464 Bezafibrate affects the expression of CYB5R3 mRNA CTD PMID:17719200 bifenthrin increases expression ISO RGD:1557763 6480464 bifenthrin results in increased expression of CYB5R3 mRNA CTD PMID:26071804 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1557763 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CYB5R3 mRNA CTD PMID:25047013 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CYB5R3 mRNA CTD PMID:30903817 bisphenol A multiple interactions ISO RGD:1557763 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A affects expression ISO RGD:2502 6480464 bisphenol A affects the expression of CYB5R3 mRNA CTD PMID:25181051 bisphenol F multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CYB5R3 mRNA CTD PMID:28628672 butan-1-ol multiple interactions EXP 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CYB5R3 mRNA CTD PMID:29432896 C60 fullerene increases expression ISO RGD:2502 6480464 fullerene C60 results in increased expression of CYB5R3 mRNA CTD PMID:19167457 carbon nanotube decreases expression ISO RGD:1557763 6480464 Nanotubes, Carbon analog results in decreased expression of CYB5R3 mRNA, Nanotubes, Carbon results in decreased expression of CYB5R3 mRNA CTD PMID:25620056 choline multiple interactions ISO RGD:1557763 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYB5R3 mRNA CTD PMID:20938992 ciglitazone multiple interactions EXP 6480464 [ciglitazone binds to PPARG protein alternative form] which results in increased expression of CYB5R3 mRNA CTD PMID:16197558 cisplatin decreases expression ISO RGD:2502 6480464 Cisplatin results in decreased expression of CYB5R3 mRNA CTD PMID:18172885 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of CYB5R3 mRNA CTD PMID:27594783 cisplatin increases expression ISO RGD:1557763 6480464 Cisplatin results in increased expression of CYB5R3 mRNA CTD PMID:21151649 clofibrate decreases expression ISO RGD:2502 6480464 Clofibrate results in decreased expression of CYB5R3 mRNA CTD PMID:12851107 , PMID:17522070 clofibric acid affects expression ISO RGD:2502 6480464 Clofibric Acid affects the expression of CYB5R3 mRNA CTD PMID:17602206 copper atom affects binding EXP 6480464 CYB5R3 protein binds to Copper CTD PMID:15359738 copper(0) affects binding EXP 6480464 CYB5R3 protein binds to Copper CTD PMID:15359738 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of CYB5R3 mRNA CTD PMID:19549813 crocidolite asbestos increases expression EXP 6480464 Asbestos, Crocidolite results in increased expression of CYB5R3 mRNA CTD PMID:29523930 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of CYB5R3 mRNA CTD PMID:20106945 dexamethasone decreases expression ISO RGD:2502 6480464 Dexamethasone results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CYB5R3 mRNA CTD PMID:28628672 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CYB5R3 mRNA CTD PMID:15725085 dibutyl phthalate decreases expression ISO RGD:2502 6480464 Dibutyl Phthalate results in decreased expression of CYB5R3 mRNA CTD PMID:21266533 erythromycin estolate decreases expression ISO RGD:2502 6480464 Erythromycin Estolate results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 ethanol increases activity ISO RGD:2502 6480464 Ethanol results in increased activity of CYB5R3 protein CTD PMID:28442378 ethanol multiple interactions ISO RGD:2502 6480464 zingerone inhibits the reaction [Ethanol results in increased activity of CYB5R3 protein] CTD PMID:28442378 flavonoids decreases expression ISO RGD:2502 6480464 Flavonoids results in decreased expression of CYB5R3 mRNA CTD PMID:18035473 flutamide increases expression ISO RGD:2502 6480464 Flutamide results in increased expression of CYB5R3 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1557763 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYB5R3 mRNA CTD PMID:20938992 genistein decreases expression ISO RGD:1557763 6480464 Genistein results in decreased expression of CYB5R3 mRNA CTD PMID:24967385 glafenine decreases expression ISO RGD:2502 6480464 Glafenine results in decreased expression of CYB5R3 mRNA CTD PMID:24136188 hydralazine multiple interactions EXP 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of CYB5R3 mRNA CTD PMID:17183730 hydroxylamine increases reduction EXP 6480464 CYB5R3 protein results in increased reduction of Hydroxylamine CTD PMID:21447608 indometacin increases expression ISO RGD:2502 6480464 Indomethacin results in increased expression of CYB5R3 mRNA CTD PMID:18299717 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CYB5R3 mRNA CTD PMID:28628672 ketamine increases expression ISO RGD:2502 6480464 Ketamine results in increased expression of CYB5R3 mRNA CTD PMID:20080153 kojic acid multiple interactions ISO RGD:2502 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNA, [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNA CTD PMID:18544905 L-methionine multiple interactions ISO RGD:1557763 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYB5R3 mRNA CTD PMID:20938992 methylmercury chloride decreases expression ISO RGD:1557763 6480464 methylmercuric chloride results in decreased expression of CYB5R3 mRNA CTD PMID:19465457 N-nitrosodiethylamine multiple interactions ISO RGD:2502 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNA, [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNA CTD PMID:18544905 N-nitrosodimethylamine decreases expression ISO RGD:2502 6480464 Dimethylnitrosamine results in decreased expression of CYB5R3 mRNA CTD PMID:14600272 NAD zwitterion multiple interactions EXP 6480464 [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine, [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NAD zwitterion affects binding EXP 6480464 CYB5R3 protein binds to NAD CTD PMID:16469290 NAD(+) multiple interactions EXP 6480464 [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine, [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NAD(+) affects binding EXP 6480464 CYB5R3 protein binds to NAD CTD PMID:16469290 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of CYB5R3 mRNA CTD PMID:19287073 paracetamol decreases expression ISO RGD:2502 6480464 Acetaminophen results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 perfluorooctanoic acid multiple interactions ISO RGD:1557763 6480464 [perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of CYB5R3 mRNA, PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of CYB5R3 mRNA] CTD PMID:20118188 , PMID:23626681 perfluorooctanoic acid decreases expression ISO RGD:1557763 6480464 perfluorooctanoic acid results in decreased expression of CYB5R3 mRNA CTD PMID:20118188 , PMID:23626681 perfluorooctanoic acid decreases expression ISO RGD:2502 6480464 perfluorooctanoic acid results in decreased expression of CYB5R3 mRNA CTD PMID:19162173 phenobarbital increases expression ISO RGD:2502 6480464 Phenobarbital results in increased expression of CYB5R3 mRNA CTD PMID:19162173 phenobarbital affects expression ISO RGD:1557763 6480464 Phenobarbital affects the expression of CYB5R3 mRNA CTD PMID:23091169 phlorizin decreases expression ISO RGD:1557763 6480464 Phlorhizin results in decreased expression of CYB5R3 mRNA CTD PMID:22538082 pirinixic acid decreases expression ISO RGD:2502 6480464 pirinixic acid results in decreased expression of CYB5R3 mRNA CTD PMID:19162173 pirinixic acid decreases expression ISO RGD:1557763 6480464 pirinixic acid results in decreased expression of CYB5R3 mRNA CTD PMID:23811191 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:2502 6480464 Pregnenolone Carbonitrile results in increased expression of CYB5R3 mRNA CTD PMID:19162173 quercetin increases expression ISO RGD:2502 6480464 Quercetin results in increased expression of CYB5R3 mRNA CTD PMID:21565894 quinidine decreases expression ISO RGD:2502 6480464 Quinidine results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 resveratrol increases expression ISO RGD:1557763 6480464 resveratrol results in increased expression of CYB5R3 protein CTD PMID:25505154 ritonavir affects expression ISO RGD:2502 6480464 Ritonavir affects the expression of CYB5R3 mRNA CTD PMID:17719200 rotenone decreases expression ISO RGD:2502 6480464 Rotenone results in decreased expression of CYB5R3 mRNA CTD PMID:28374803 sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of CYB5R3 mRNA CTD PMID:29319823 sodium dichromate increases expression ISO RGD:2502 6480464 sodium bichromate results in increased expression of CYB5R3 mRNA CTD PMID:12325037 sodium fluoride decreases expression ISO RGD:1557763 6480464 Sodium Fluoride results in decreased expression of CYB5R3 protein CTD PMID:28918527 Soman increases expression ISO RGD:2502 6480464 Soman results in increased expression of CYB5R3 mRNA CTD PMID:19281266 sulfamethoxazole hydroxylamine multiple interactions EXP 6480464 [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine, [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 tamoxifen decreases expression ISO RGD:1557763 6480464 Tamoxifen results in decreased expression of CYB5R3 mRNA CTD PMID:25123088 tetrachloromethane decreases expression ISO RGD:2502 6480464 Carbon Tetrachloride results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 , PMID:31150632 tetrachloromethane decreases expression ISO RGD:1557763 6480464 Carbon Tetrachloride results in decreased expression of CYB5R3 mRNA CTD PMID:27339419 tetracycline decreases expression ISO RGD:2502 6480464 Tetracycline results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 thimerosal decreases expression EXP 6480464 Thimerosal results in decreased expression of CYB5R3 mRNA CTD PMID:27188386 thioacetamide decreases expression ISO RGD:2502 6480464 Thioacetamide results in decreased expression of CYB5R3 mRNA CTD PMID:23411599 titanium dioxide increases expression ISO RGD:1557763 6480464 titanium dioxide results in increased expression of CYB5R3 mRNA CTD PMID:29264374 tunicamycin decreases expression EXP 6480464 Tunicamycin results in decreased expression of CYB5R3 mRNA CTD PMID:22378314 valproic acid increases methylation EXP 6480464 Valproic Acid results in increased methylation of CYB5R3 gene CTD PMID:29154799 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of CYB5R3 mRNA CTD PMID:25979313 valproic acid multiple interactions EXP 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of CYB5R3 mRNA CTD PMID:17183730 valproic acid increases expression ISO RGD:1557763 6480464 Valproic Acid results in increased expression of CYB5R3 mRNA CTD PMID:21427059 vinclozolin affects expression ISO RGD:2502 6480464 vinclozolin affects the expression of CYB5R3 mRNA CTD PMID:19015723 vinclozolin increases expression ISO RGD:2502 6480464 vinclozolin results in increased expression of CYB5R3 mRNA CTD PMID:22570695 zinc atom affects expression EXP 6480464 Zinc affects the expression of CYB5R3 mRNA CTD PMID:16979875 zinc(0) affects expression EXP 6480464 Zinc affects the expression of CYB5R3 mRNA CTD PMID:16979875 zingerone multiple interactions ISO RGD:2502 6480464 zingerone inhibits the reaction [Ethanol results in increased activity of CYB5R3 protein] CTD PMID:28442378 zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of CYB5R3 mRNA CTD PMID:20977926
Gene-Chemical Interaction Annotations
