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Gene: CYB5R3 (cytochrome b5 reductase 3) Homo sapiens
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Symbol: CYB5R3
Name: cytochrome b5 reductase 3
Description: Exhibits FAD binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; neutrophil degranulation; and xenobiotic metabolic process. Localizes to the endoplasmic reticulum and lipid droplet. Implicated in breast cancer and methemoglobinemia. Biomarker of estrogen-receptor negative breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B5R; DIA1; diaphorase 1; diaphorase-1; mutant NADH-cytochrome b5 reductase; NADH-cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form
Orthologs:
Mus musculus (house mouse) : Cyb5r3 (cytochrome b5 reductase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyb5r3 (cytochrome b5 reductase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102012303 (NADH-cytochrome b5 reductase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100982559 (NADH-cytochrome b5 reductase 3)
Canis lupus familiaris (dog) : CYB5R3 (cytochrome b5 reductase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101962805 (NADH-cytochrome b5 reductase 3)
Sus scrofa (pig) : LOC100524254 (NADH-cytochrome b5 reductase 3-like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382242,617,840 - 42,649,392 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372243,013,846 - 43,045,405 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,344,763 - 41,375,349 (-)NCBINCBI36hg18NCBI36
Build 342241,339,318 - 41,367,516NCBI
Celera2226,924,326 - 26,955,882 (-)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2225,974,473 - 26,005,949 (-)NCBIHuRef
CHM1_12242,972,995 - 43,004,519 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CYB5R3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731731
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.