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Gene: ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) Homo sapiens
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Symbol: ATP2A2
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Description: Exhibits several functions, including S100 protein binding activity; ion channel binding activity; and protein C-terminus binding activity. Involved in several processes, including calcium ion transport from cytosol to endoplasmic reticulum; positive regulation of endoplasmic reticulum calcium ion concentration; and regulation of cardiac muscle contraction by calcium ion signaling. Localizes to the calcium ion-transporting ATPase complex; endoplasmic reticulum membrane; and longitudinal sarcoplasmic reticulum. Colocalizes with the intercalated disc. Implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP2B; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; DAR; DD; DKFZp686P0211; endoplasmic reticulum class 1/2 Ca(2+) ATPase; FLJ20293; FLJ38063; MGC45367; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812110,281,247 - 110,351,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712110,719,032 - 110,788,898 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612109,203,815 - 109,273,278 (+)NCBINCBI36hg18NCBI36
Build 3412109,182,151 - 109,251,615NCBI
Celera12110,344,773 - 110,414,642 (+)NCBI
Cytogenetic Map12q24.11NCBI
HuRef12107,737,670 - 107,807,502 (+)NCBIHuRef
CHM1_112110,686,837 - 110,756,707 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

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Position Markers
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Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ATP2A2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731733
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.