Gene: PTPN11 (protein tyrosine phosphatase non-receptor type 11) Homo sapiens
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Symbol: PTPN11
Name: protein tyrosine phosphatase non-receptor type 11
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BPTP3; CFC; JMML; METCDS; MGC14433; NS1; protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1); protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; PTP-1D; PTP-2C; PTP2C; SH-PTP2; SH-PTP3; SHP2; tyrosine-protein phosphatase non-receptor type 11
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,418,898 - 112,509,918 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712112,856,536 - 112,947,717 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,340,919 - 111,432,100 (+)NCBINCBI36hg18NCBI36
Build 3412111,319,255 - 111,410,436NCBI
Celera12112,483,686 - 112,574,781 (+)NCBI
Cytogenetic Map12q24.13NCBI
HuRef12109,868,826 - 109,960,330 (+)NCBIHuRef
CHM1_112112,825,224 - 112,916,404 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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