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Gene: Ptpn11 (protein tyrosine phosphatase, non-receptor type 11) Mus musculus
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Symbol: Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Description: Exhibits cell adhesion molecule binding activity; protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and regulation of hormone secretion. Predicted to localize to several cellular components, including the cell junction; mitochondrion; and stress fiber. Used to study several diseases, including LEOPARD syndrome; Noonan syndrome 1; hepatocellular adenoma; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in LEOPARD syndrome (multiple); Noonan syndrome (multiple); chondroma; juvenile myelomonocytic leukemia; and tetralogy of Fallot. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 1,4-dichlorobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2700084A17Rik; AW536184; protein-tyrosine phosphatase SYP; PTP1D; PTP2C; SAP-2; SH-PTP2; SH-PTP3; SH2 domain-containing protein tyrosine phosphatase-2; SHP-2; Shp2; Syp; tyrosine-protein phosphatase non-receptor type 11
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5121,130,533 - 121,191,397 (-)Ensembl
GRCm385121,130,533 - 121,191,397 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375121,580,542 - 121,641,406 (-)NCBIGRCm37mm9NCBIm37
MGSCv365121,391,158 - 121,451,946 (-)NCBImm8
Celera5118,220,712 - 118,281,623 (-)NCBICelera
Cytogenetic Map5 FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ptpn11
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731747
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.