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Gene: PTPRO (protein tyrosine phosphatase receptor type O) Homo sapiens
Symbol: PTPRO
Name: protein tyrosine phosphatase receptor type O
Description: Exhibits cadherin binding activity and protein tyrosine phosphatase activity. Involved in glomerulus development; monocyte chemotaxis; and peptidyl-tyrosine dephosphorylation. Localizes to the extracellular exosome. Implicated in nephrotic syndrome type 6.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GLEPP1; glomerular epithelial protein 1; glomerular epithelial protein-1; NPHS6; osteoclastic transmembrane protein-tyrosine phosphatase; phosphotyrosine phosphatase U2; protein tyrosine phosphatase PTP-U2; protein tyrosine phosphatase U2; PTP phi; PTP-oc; PTP-U2; PTPase U2; PTPROT; PTPU2; R-PTP-O; receptor-type protein tyrosine phosphatase O; receptor-type tyrosine-protein phosphatase O
Mus musculus (house mouse) : Ptpro (protein tyrosine phosphatase, receptor type, O)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptpro (protein tyrosine phosphatase, receptor type, O)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpro (protein tyrosine phosphatase receptor type O)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRO (protein tyrosine phosphatase receptor type O)
Canis lupus familiaris (dog) : PTPRO (protein tyrosine phosphatase receptor type O)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpro (protein tyrosine phosphatase receptor type O)
Sus scrofa (pig) : PTPRO (protein tyrosine phosphatase receptor type O)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381215,322,334 - 15,598,331 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371215,475,191 - 15,751,265 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361215,366,754 - 15,641,602 (+)NCBINCBI36hg18NCBI36
Build 341215,590,552 - 15,641,602NCBI
Celera1220,620,432 - 20,895,225 (+)NCBI
Cytogenetic Map12p12.3NCBI
HuRef1215,244,485 - 15,520,600 (+)NCBIHuRef
CHM1_11215,441,256 - 15,717,221 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPRO
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731757
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.