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Gene: NR1D1 (nuclear receptor subfamily 1 group D member 1) Homo sapiens
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Symbol: NR1D1
Name: nuclear receptor subfamily 1 group D member 1
CRRD ID: 731848
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; heme binding activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of macromolecule biosynthetic process; and negative regulation of toll-like receptor 4 signaling pathway. Localizes to nuclear body and nuclear chromatin. Biomarker of alcoholic liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ear-1; EAR1; hRev; nuclear receptor Rev-ErbA-alpha; nuclear receptor subfamily 1, group D, member 1; rev-erbA-alpha; Rev-ErbAalpha; REVERBA; REVERBalpha; THRA1; THRAL; thyroid hormone receptor, alpha-like; V-erbA-related protein 1
Orthologs:
Mus musculus (house mouse) : Nr1d1 (nuclear receptor subfamily 1, group D, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nr1d1 (nuclear receptor subfamily 1, group D, member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1d1 (nuclear receptor subfamily 1 group D member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1D1 (nuclear receptor subfamily 1 group D member 1)
Canis lupus familiaris (dog) : NR1D1 (nuclear receptor subfamily 1 group D member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1d1 (nuclear receptor subfamily 1 group D member 1)
Sus scrofa (pig) : NR1D1 (nuclear receptor subfamily 1 group D member 1)
Chlorocebus sabaeus (African green monkey) : NR1D1 (nuclear receptor subfamily 1 group D member 1)
Heterocephalus glaber (naked mole-rat) : Nr1d1 (nuclear receptor subfamily 1 group D member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1740,092,793 - 40,100,589 (-)EnsemblGRCh38hg38GRCh38
GRCh381740,092,793 - 40,100,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371738,249,037 - 38,256,978 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,502,567 - 35,510,499 (-)NCBINCBI36hg18NCBI36
Build 341735,502,566 - 35,510,499NCBI
Celera1734,909,147 - 34,917,084 (-)NCBI
Cytogenetic Map17q21.1NCBI
HuRef1734,042,773 - 34,050,715 (-)NCBIHuRef
CHM1_11738,484,740 - 38,492,682 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NR1D1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731848
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-10-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.