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Gene: PAK3 (p21 (RAC1) activated kinase 3) Homo sapiens
Symbol: PAK3
Name: p21 (RAC1) activated kinase 3
Description: The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adriamycin resistance-associated; ARA; beta-PAK; bPAK; CDKN1A; hPAK3; mental retardation, X-linked 47; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; PAK-3; PAK3beta; serine/threonine-protein kinase PAK 3
Mus musculus (house mouse) : Pak3 (p21 (RAC1) activated kinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pak3 (p21 (RAC1) activated kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak3 (p21 (RAC1) activated kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK3 (p21 (RAC1) activated kinase 3)
Canis lupus familiaris (dog) : PAK3 (p21 (RAC1) activated kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak3 (p21 (RAC1) activated kinase 3)
Sus scrofa (pig) : PAK3 (p21 (RAC1) activated kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X110,944,241 - 111,227,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X110,187,513 - 110,470,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,226,256 - 110,350,816 (+)NCBINCBI36hg18NCBI36
Build 34X110,145,744 - 110,270,305NCBI
CeleraX110,667,132 - 110,943,790 (+)NCBI
Cytogenetic MapXq23NCBI
HuRefX99,807,691 - 100,086,683 (+)NCBIHuRef
CHM1_1X110,098,813 - 110,382,089 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PAK3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731864
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.