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Gene: Syk (spleen tyrosine kinase) Mus musculus
Symbol: Syk
Name: spleen tyrosine kinase
Description: Exhibits several functions, including ATP binding activity; SH2 domain binding activity; and enzyme binding activity. Involved in several processes, including positive regulation of cytokine production; protein phosphorylation; and regulation of leukocyte activation. Localizes to the B cell receptor complex and early phagosome. Is expressed in liver. Orthologous to human SYK (spleen associated tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH 2-butoxyethanol; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Sykb; tyrosine-protein kinase SYK
Homo sapiens (human) : SYK (spleen associated tyrosine kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Syk (spleen associated tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Syk (spleen associated tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : SYK (spleen associated tyrosine kinase)
Canis lupus familiaris (dog) : SYK (spleen associated tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Syk (spleen associated tyrosine kinase)
Sus scrofa (pig) : SYK (spleen associated tyrosine kinase)
Chlorocebus sabaeus (green monkey) : SYK (spleen associated tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Syk (spleen associated tyrosine kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1352,583,173 - 52,648,792 (+)Ensembl
GRCm381352,582,610 - 52,648,792 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371352,692,251 - 52,744,161 (+)NCBIGRCm37mm9NCBIm37
MGSCv361352,609,314 - 52,661,224 (+)NCBImm8
Celera1353,659,971 - 53,725,528 (+)NCBICelera
Cytogenetic Map13 A5NCBI
cM Map1327.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Syk
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731871
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.