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Gene: CAPN3 (calpain 3) Homo sapiens
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Symbol: CAPN3
Name: calpain 3
Description: Exhibits ligase regulator activity; peptidase activity; and titin binding activity. Involved in several processes, including calcium-dependent self proteolysis; protein destabilization; and regulation of transcription, DNA-templated. Localizes to the cytoplasm and nucleus. Implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: calcium-activated neutral proteinase 3; calpain 3, (p94); calpain L3; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; calpain-3; CANP 3; CANP3; CANPL3; LGMD2; LGMD2A; LGMDD4; LGMDR1; MGC10767; MGC11121; MGC14344; MGC4403; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; new calpain 1; p94
Orthologs:
Mus musculus (house mouse) : Capn3 (calpain 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Capn3 (calpain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Capn3 (calpain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CAPN3 (calpain 3)
Canis lupus familiaris (dog) : CAPN3 (calpain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Capn3 (calpain 3)
Sus scrofa (pig) : CAPN3 (calpain 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1542,359,498 - 42,412,949 (+)Ensembl
GRCh38 Ensembl1542,359,500 - 42,412,318 (+)Ensembl
GRCh381542,359,500 - 42,412,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371542,646,545 - 42,704,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361540,427,593 - 40,491,807 (+)NCBINCBI36hg18NCBI36
Build 341540,427,592 - 40,491,807NCBI
Celera1519,408,011 - 19,472,224 (+)NCBI
Cytogenetic Map15q15.1NCBI
HuRef1519,499,872 - 19,552,636 (+)NCBIHuRef
CHM1_11542,770,186 - 42,823,000 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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