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Gene: Nkx2-5 (NK2 homeobox 5) Mus musculus
Symbol: Nkx2-5
Name: NK2 homeobox 5
CRRD ID: 731878
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including circulatory system development; regulation of heart contraction; and regulation of transcription by RNA polymerase II. Localizes to cytoplasm; nucleus; and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; gut; heart; and hemolymphoid system. Used to study atrial heart septal defect 7; congenital heart disease; hypoplastic left heart syndrome; and tetralogy of Fallot. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cardiac-specific homeobox; Cs; Csx; Drosophila NK2 transcription factor related, locus 5; homeobox protein CSX; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; Nkx-2.; Nkx-2.5; Nkx2.; Nkx2.5; ti; tinman
Homo sapiens (human) : NKX2-5 (NK2 homeobox 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nkx2-5 (NK2 homeobox 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-5 (NK2 homeobox 5)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-5 (NK2 homeobox 5)
Canis lupus familiaris (dog) : NKX2-5 (NK2 homeobox 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-5 (NK2 homeobox 5)
Sus scrofa (pig) : NKX2-5 (NK2 homeobox 5)
Chlorocebus sabaeus (African green monkey) : NKX2-5 (NK2 homeobox 5)
Heterocephalus glaber (naked mole-rat) : Nkx2-5 (NK2 homeobox 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391727,057,638 - 27,063,962 (-)NCBI
GRCm381726,838,664 - 26,844,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,838,664 - 26,845,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,975,610 - 26,978,510 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,566,254 - 26,569,154 (-)NCBImm8
Celera1727,375,289 - 27,378,187 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Nkx2-5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731878
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.