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Gene: Nkx2-5 (NK2 homeobox 5) Mus musculus
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Symbol: Nkx2-5
Name: NK2 homeobox 5
CRRD ID: 731878
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including circulatory system development; regulation of heart contraction; and regulation of transcription by RNA polymerase II. Localizes to cytoplasm; nucleus; and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; gut; heart; and hemolymphoid system. Used to study atrial heart septal defect 7; congenital heart disease; hypoplastic left heart syndrome; and tetralogy of Fallot. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cardiac-specific homeobox; Cs; Csx; Drosophila NK2 transcription factor related, locus 5; homeobox protein CSX; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; Nkx-2.; Nkx-2.5; Nkx2.; Nkx2.5; ti; tinman
Orthologs:
Homo sapiens (human) : NKX2-5 (NK2 homeobox 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nkx2-5 (NK2 homeobox 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-5 (NK2 homeobox 5)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-5 (NK2 homeobox 5)
Canis lupus familiaris (dog) : NKX2-5 (NK2 homeobox 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-5 (NK2 homeobox 5)
Sus scrofa (pig) : NKX2-5 (NK2 homeobox 5)
Chlorocebus sabaeus (African green monkey) : NKX2-5 (NK2 homeobox 5)
Heterocephalus glaber (naked mole-rat) : Nkx2-5 (NK2 homeobox 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,057,638 - 27,063,962 (-)NCBI
GRCm381726,838,664 - 26,844,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,838,664 - 26,845,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,975,610 - 26,978,510 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,566,254 - 26,569,154 (-)NCBImm8
Celera1727,375,289 - 27,378,187 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Nkx2-5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731878
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.